4TU8

STRUCTURE OF U2AF65 VARIANT WITH BRU5A6 DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue DIO A 401

Chain	Residue
A	ASN268
A	TYR269
A	LEU270
A	ASN271
A	GLY297
A	LEU298
A	SER299

---

site_id	AC2
Number of Residues	5
Details	binding site for residue DIO A 402

Chain	Residue
A	TYR232
A	GLN233
A	LEU325
A	PRO144
A	ALA148

---

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 403

Chain	Residue
A	GLY146
A	SER147
A	ALA148
A	ARG150
A	SER281
A	HOH515

---

site_id	AC4
Number of Residues	1
Details	binding site for residue EDO A 404

Chain	Residue
A	LEU285

---

site_id	AC5
Number of Residues	8
Details	binding site for residue EDO A 405

Chain	Residue
A	VAL205
A	ASP206
A	GLY319
A	LEU320
A	ASN321
A	MET323
A	LYS329
A	HOH501

---

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO A 406

Chain	Residue
A	ARG150
A	GLN190
A	GLU201

---

site_id	AC7
Number of Residues	2
Details	binding site for residue EDO A 408

Chain	Residue
A	PRO144
A	GLN274

---

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 A 409

Chain	Residue
A	LYS225
A	ARG227

---

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 A 410

Chain	Residue
A	ARG228
A	ILE310
A	HOH639

---

site_id	AD1
Number of Residues	3
Details	binding site for residue DIO B 401

Chain	Residue
B	LYS276
B	LEU285
B	LYS286

---

site_id	AD2
Number of Residues	4
Details	binding site for residue DIO B 402

Chain	Residue
B	PRO182
B	GLY183
B	HIS259
B	HOH507

---

site_id	AD3
Number of Residues	8
Details	binding site for residue DIO B 403

Chain	Residue
B	ASN268
B	TYR269
B	LEU270
B	ASN271
B	GLY297
B	LEU298
B	SER299
B	HOH522

---

site_id	AD4
Number of Residues	3
Details	binding site for residue DIO B 404

Chain	Residue
B	SER204
B	VAL205
B	HOH549

---

site_id	AD5
Number of Residues	3
Details	binding site for residue DIO B 405

Chain	Residue
B	ARG228
B	HOH598
B	HOH622

---

site_id	AD6
Number of Residues	8
Details	binding site for residue CPQ B 406

Chain	Residue
B	TYR269
B	TYR269
B	GLN274
B	GLY326
B	EDO408
B	EDO409
B	HOH596
B	HOH615

---

site_id	AD7
Number of Residues	6
Details	binding site for residue EDO B 407

Chain	Residue
B	LYS292
B	ASP293
B	SER294
B	LYS300
P	BRU5
P	DA6

---

site_id	AD8
Number of Residues	2
Details	binding site for residue EDO B 408

Chain	Residue
B	ASP327
B	CPQ406

---

site_id	AD9
Number of Residues	1
Details	binding site for residue EDO B 409

Chain	Residue
B	CPQ406

---

site_id	AE1
Number of Residues	4
Details	binding site for residue EDO B 410

Chain	Residue
B	ALA318
B	GLY319
B	ASN321
B	MET323

---

site_id	AE2
Number of Residues	4
Details	binding site for residue SO4 B 411

Chain	Residue
A	ARG174
B	LYS225
B	ARG227
E	HOH109

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	164
Details	Domain: {"description":"RRM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"5-hydroxylysine; by JMJD6","evidences":[{"source":"PubMed","id":"19574390","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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