8SBX
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![BU of 8sbx by Molmil](/molmil-images/mine/8sbx) | Crystal Structure of 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase from Klebsiella aerogenes (Apo, hexagonal form) | Descriptor: | 2,3-dihydroxybenzoate-2,3-dehydrogenase, CHLORIDE ION, SULFATE ION | Authors: | Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2023-04-04 | Release date: | 2023-04-12 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase from Klebsiella aerogenes (Apo, hexagonal form) To be published
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6Q0W
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![BU of 6q0w by Molmil](/molmil-images/mine/6q0w) | Structure of DDB1-DDA1-DCAF15 complex bound to Indisulam and RBM39 | Descriptor: | DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, ... | Authors: | Faust, T, Yoon, H, Nowak, R.P, Donovan, K.A, Li, Z, Cai, Q, Eleuteri, N.A, Zhang, T, Gray, N.S, Fischer, E.S. | Deposit date: | 2019-08-02 | Release date: | 2019-11-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat.Chem.Biol., 16, 2020
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7ZTN
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![BU of 7ztn by Molmil](/molmil-images/mine/7ztn) | Crystal structure of fungal CE16 acetyl xylan esterase | Descriptor: | 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Dimarogona, M, Kosinas, C, Pentari, C, Zerva, A, Topakas, E. | Deposit date: | 2022-05-10 | Release date: | 2023-08-23 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The role of CE16 exo-deacetylases in hemicellulolytic enzyme mixtures revealed by the biochemical and structural study of the novel TtCE16B esterase. Carbohydr Polym, 327, 2024
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6FBU
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![BU of 6fbu by Molmil](/molmil-images/mine/6fbu) | Crystal structure of the DNA repair enzyme endonuclease-VIII (Nei) from E. coli (E2Q) in complex with AP-site containing DNA substrate | Descriptor: | ACETATE ION, DNA (5'-D(P*CP*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3'), DNA (5'-D(P*GP*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*G)-3'), ... | Authors: | Pomyalov, S, Lansky, S, Golan, G, Zharkov, D.O, Grollman, A.P, Shoham, G. | Deposit date: | 2017-12-19 | Release date: | 2019-01-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the DNA repair enzyme endonuclease-VIII (Nei) from E. coli (E2Q) in complex with AP-site containing DNA substrate To Be Published
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6CD9
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![BU of 6cd9 by Molmil](/molmil-images/mine/6cd9) | GID4 in complex with a peptide | Descriptor: | Glucose-induced degradation protein 4 homolog, Tetrapeptide PSRW, UNKNOWN ATOM OR ION | Authors: | Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2018-02-08 | Release date: | 2018-03-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. Nat. Chem. Biol., 14, 2018
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5UJ7
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![BU of 5uj7 by Molmil](/molmil-images/mine/5uj7) | Structure of the active form of human Origin Recognition Complex ATPase motor module, complex subunitS 1, 4, 5 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... | Authors: | Tocilj, A, Elkayam, E, On, K.F, Joshua-Tor, L. | Deposit date: | 2017-01-17 | Release date: | 2017-02-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.394 Å) | Cite: | Structure of the active form of human Origin Recognition Complex and its ATPase motor module. Elife, 6, 2017
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7KJZ
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![BU of 7kjz by Molmil](/molmil-images/mine/7kjz) | crystal structure of PLEKHA7 PH domain biding inositol-tetraphosphate | Descriptor: | 1,2-ETHANEDIOL, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, Pleckstrin homology domain-containing family A member 7 | Authors: | Marassi, F.M, Aleshin, A.E, Liddington, R.C. | Deposit date: | 2020-10-26 | Release date: | 2021-04-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids. Structure, 29, 2021
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6FGZ
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![BU of 6fgz by Molmil](/molmil-images/mine/6fgz) | Cyanidioschyzon merolae Dnm1 (CmDnm1) | Descriptor: | Dynamin | Authors: | Bohuszewicz, O, Low, H.H. | Deposit date: | 2018-01-11 | Release date: | 2018-08-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (7.002 Å) | Cite: | Structure of a mitochondrial fission dynamin in the closed conformation. Nat. Struct. Mol. Biol., 25, 2018
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6CDA
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![BU of 6cda by Molmil](/molmil-images/mine/6cda) | Crystal structure of L34A CzrA in the Zn(II)bound state | Descriptor: | ArsR family transcriptional regulator, CHLORIDE ION, GLYCEROL, ... | Authors: | Capdevila, D.A, Gonzalez-Gutierrez, G, Giedroc, D.P. | Deposit date: | 2018-02-08 | Release date: | 2018-07-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Functional Role of Solvent Entropy and Conformational Entropy of Metal Binding in a Dynamically Driven Allosteric System. J. Am. Chem. Soc., 140, 2018
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6YB4
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![BU of 6yb4 by Molmil](/molmil-images/mine/6yb4) | |
7ZG3
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![BU of 7zg3 by Molmil](/molmil-images/mine/7zg3) | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH011228 | Descriptor: | N-glycosylase/DNA lyase, NICKEL (II) ION, ~{N}-[(1~{S})-1,2,2-trimethylcyclopropyl]pyrrolo[1,2-c]pyrimidine-3-carboxamide | Authors: | Davies, J.R, Scaletti, E, Stenmark, P. | Deposit date: | 2022-04-01 | Release date: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH011228 To Be Published
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6Q2F
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![BU of 6q2f by Molmil](/molmil-images/mine/6q2f) | Structure of Rhamnosidase from Novosphingobium sp. PP1Y | Descriptor: | Glycoside hydrolase family protein, SODIUM ION | Authors: | Terry, B, Ha, J, Izzo, V, Sazinsky, M.H. | Deposit date: | 2019-08-07 | Release date: | 2019-11-27 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.20000076 Å) | Cite: | The crystal structure and insight into the substrate specificity of the alpha-L rhamnosidase RHA-P from Novosphingobium sp. PP1Y. Arch.Biochem.Biophys., 679, 2019
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6FC3
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![BU of 6fc3 by Molmil](/molmil-images/mine/6fc3) | |
8SA8
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![BU of 8sa8 by Molmil](/molmil-images/mine/8sa8) | |
5UKF
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![BU of 5ukf by Molmil](/molmil-images/mine/5ukf) | Crystal Structure of the Human Vaccinia-related Kinase 1 Bound to an Oxindole Inhibitor | Descriptor: | 4-{[(Z)-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}benzene-1-sulfonamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Counago, R.M, Wells, C, Zuercher, W, Willson, T.M, Bountra, C, Edwards, A.M, Arruda, P, Gileadi, O, Structural Genomics Consortium (SGC) | Deposit date: | 2017-01-22 | Release date: | 2017-03-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Sci Rep, 7, 2017
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7KWW
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![BU of 7kww by Molmil](/molmil-images/mine/7kww) | X-ray Crystal Structure of PlyCB Mutant K59H | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, PlyCB | Authors: | Williams, D.E, Broendum, S.S, Hayes, B.K, Drinkwater, N, McGowan, S. | Deposit date: | 2020-12-02 | Release date: | 2021-04-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | High avidity drives the interaction between the streptococcal C1 phage endolysin, PlyC, with the cell surface carbohydrates of Group A Streptococcus. Mol.Microbiol., 116, 2021
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8SAB
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![BU of 8sab by Molmil](/molmil-images/mine/8sab) | |
5VB7
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![BU of 5vb7 by Molmil](/molmil-images/mine/5vb7) | X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with an agonist and SRC2 peptide | Descriptor: | N-methyl-N'-(3-methylbut-2-en-1-yl)-N'-(3-phenoxyphenyl)-N-[trans-4-(pyridin-4-yl)cyclohexyl]urea, Nuclear receptor ROR-gamma, SRC2 chimera, ... | Authors: | Li, X. | Deposit date: | 2017-03-28 | Release date: | 2017-06-07 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.335 Å) | Cite: | Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors. J. Biol. Chem., 292, 2017
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6Y4S
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6Y58
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![BU of 6y58 by Molmil](/molmil-images/mine/6y58) | Binary complex of 14-3-3 sigma (C38N) with the Estrogen Related Receptor gamma (LBD) phosphopeptide | Descriptor: | 14-3-3 protein sigma, Estrogen Related Receptor gamma phosphopeptide, MAGNESIUM ION | Authors: | Somsen, B.A, Sijbesma, E, Leijten-van de Gevel, I.A, Ottmann, C. | Deposit date: | 2020-02-25 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.904 Å) | Cite: | Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. Acs Chem.Biol., 15, 2020
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7KK7
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![BU of 7kk7 by Molmil](/molmil-images/mine/7kk7) | crystal structure of ligand-free PLEKHA7 PH domain | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Pleckstrin homology domain-containing family A member 7 | Authors: | Marassi, F.M, Aleshin, A.E, Liddington, R.C. | Deposit date: | 2020-10-27 | Release date: | 2021-04-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids. Structure, 29, 2021
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8SAD
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![BU of 8sad by Molmil](/molmil-images/mine/8sad) | |
8A0S
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![BU of 8a0s by Molmil](/molmil-images/mine/8a0s) | MTH1 in complex with TH013350 | Descriptor: | 4-[(2-chlorophenyl)methylsulfanyl]-5~{H}-pyrimidin-2-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION | Authors: | Liu, H, Scaletti, E, Stenmark, P. | Deposit date: | 2022-05-30 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | MTH1 in complex with TH013350 To Be Published
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6Q3K
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![BU of 6q3k by Molmil](/molmil-images/mine/6q3k) | Engineered Human HLA_A2 MHC Class I molecule in complex with NV9 peptide | Descriptor: | ASN-LEU-VAL-PRO-MET-VAL-ALA-THR-VAL, Beta-2-microglobulin, COBALT (II) ION, ... | Authors: | Meijers, R, Anjanappa, R, Springer, S, Garcia-Alai, M. | Deposit date: | 2018-12-04 | Release date: | 2019-07-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Engineered Human HLA_A2MHC Class I molecule in complex with NV9 peptide Sci Immunol, 2019
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7Q2I
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![BU of 7q2i by Molmil](/molmil-images/mine/7q2i) | Crystal structure of the C-terminal catalytic domain of Plasmodium falciparum CTP:phosphocholine cytidylyltransferase with Tetrahydrofurfurylamine | Descriptor: | 1-[(2R)-oxolan-2-yl]methanamine, Cholinephosphate cytidylyltransferase, Guanidinium | Authors: | Duclovel, C, Gelin, M, Krimm, I, Cerdan, R, Guichou, J.-F. | Deposit date: | 2021-10-25 | Release date: | 2022-11-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design of PfCCT inhibitors To Be Published
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