6YB4
Crystal structure of human ATAD2 bromodomain in complex with N-(4-bromo-3-(3-methylpyrrolidin-1-yl)sulfonyl)phenyl)-2-(-4-cyclopropyl-4-methyl-2,5-dioxoimidazolidin-1-yl)acetamide
This is a non-PDB format compatible entry.
Summary for 6YB4
Entry DOI | 10.2210/pdb6yb4/pdb |
Descriptor | ATPase family AAA domain-containing protein 2, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | inhibitor, atad2, bromodomain, epigenetics, atpase family aaa domain-containing protein 2, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16345.25 |
Authors | Chung, C. (deposition date: 2020-03-15, release date: 2020-05-06, Last modification date: 2020-06-10) |
Primary citation | Lucas, S.C.C.,Atkinson, S.J.,Bamborough, P.,Barnett, H.,Chung, C.W.,Gordon, L.,Mitchell, D.J.,Phillipou, A.,Prinjha, R.K.,Sheppard, R.J.,Tomkinson, N.C.O.,Watson, R.J.,Demont, E.H. Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode. J.Med.Chem., 63:5212-5241, 2020 Cited by PubMed: 32321240DOI: 10.1021/acs.jmedchem.0c00021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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