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5UKF

Crystal Structure of the Human Vaccinia-related Kinase 1 Bound to an Oxindole Inhibitor

Summary for 5UKF
Entry DOI10.2210/pdb5ukf/pdb
DescriptorSerine/threonine-protein kinase VRK1, 4-{[(Z)-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}benzene-1-sulfonamide, PHOSPHATE ION, ... (6 entities in total)
Functional Keywordstransferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight166712.96
Authors
Counago, R.M.,Wells, C.,Zuercher, W.,Willson, T.M.,Bountra, C.,Edwards, A.M.,Arruda, P.,Gileadi, O.,Structural Genomics Consortium (SGC) (deposition date: 2017-01-22, release date: 2017-03-29, Last modification date: 2023-10-04)
Primary citationCounago, R.M.,Allerston, C.K.,Savitsky, P.,Azevedo, H.,Godoi, P.H.,Wells, C.I.,Mascarello, A.,de Souza Gama, F.H.,Massirer, K.B.,Zuercher, W.J.,Guimaraes, C.R.W.,Gileadi, O.
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
Sci Rep, 7:7501-7501, 2017
Cited by
PubMed: 28790404
DOI: 10.1038/s41598-017-07755-y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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