6Q0W

Structure of DDB1-DDA1-DCAF15 complex bound to Indisulam and RBM39

Summary for 6Q0W

Entry DOI	10.2210/pdb6q0w/pdb
Descriptor	DNA damage-binding protein 1, DDB1- and CUL4-associated factor 15, RNA-binding protein 39, ... (8 entities in total)
Functional Keywords	ubiquitin, homeostasis, targeted protein degradation, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	5
Total formula weight	184986.14
Authors	Faust, T.,Yoon, H.,Nowak, R.P.,Donovan, K.A.,Li, Z.,Cai, Q.,Eleuteri, N.A.,Zhang, T.,Gray, N.S.,Fischer, E.S. (deposition date: 2019-08-02, release date: 2019-11-13, Last modification date: 2023-10-11)
Primary citation	Faust, T.B.,Yoon, H.,Nowak, R.P.,Donovan, K.A.,Li, Z.,Cai, Q.,Eleuteri, N.A.,Zhang, T.,Gray, N.S.,Fischer, E.S. Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat.Chem.Biol., 16:7-14, 2020 Cited by PubMed: 31686031 DOI: 10.1038/s41589-019-0378-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation