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5FLV
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BU of 5flv by Molmil
Crystal structure of NKX2-5 and TBX5 bound to the Nppa promoter region
Descriptor: 5'-D(*AP*CP*CP*AP*CP*TP*TP*CP*AP*AP*AP*GP*GP*TP *GP*TP*GP*AP*GP*AP*AP*G)-3', 5'-D(*TP*CP*TP*TP*CP*TP*CP*AP*CP*AP*CP*CP*TP*TP *TP*GP*AP*AP*GP*TP*GP*G)-3', HOMEOBOX PROTEIN NKX-2.5, ...
Authors:Stirnimann, C.U, Glatt, S, Mueller, C.W.
Deposit date:2015-10-28
Release date:2016-02-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.
Cell(Cambridge,Mass.), 164, 2016
1MH3
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BU of 1mh3 by Molmil
maltose binding-a1 homeodomain protein chimera, crystal form I
Descriptor: maltose binding-a1 homeodomain protein chimera
Authors:Ke, A, Wolberger, C.
Deposit date:2002-08-19
Release date:2002-09-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera
Protein Sci., 12, 2003
1MH4
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BU of 1mh4 by Molmil
maltose binding-a1 homeodomain protein chimera, crystal form II
Descriptor: maltose binding-a1 homeodomain protein chimera
Authors:Ke, A, Wolberger, C.
Deposit date:2002-08-19
Release date:2002-09-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera
Protein Sci., 12, 2003
1MNM
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BU of 1mnm by Molmil
YEAST MATALPHA2/MCM1/DNA TERNARY TRANSCRIPTION COMPLEX CRYSTAL STRUCTURE
Descriptor: DNA (STE6 OPERATOR DNA), PROTEIN (MAT ALPHA-2 TRANSCRIPTIONAL REPRESSOR), PROTEIN (MCM1 TRANSCRIPTIONAL REGULATOR)
Authors:Tan, S, Richmond, T.J.
Deposit date:1997-11-03
Release date:1998-03-18
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of the yeast MATalpha2/MCM1/DNA ternary complex.
Nature, 391, 1998
2R5Y
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BU of 2r5y by Molmil
Structure of Scr/Exd complex bound to a consensus Hox-Exd site
Descriptor: DNA (5'-D(*DAP*DCP*DTP*DCP*DTP*DAP*DTP*DGP*DAP*DTP*DTP*DTP*DAP*DTP*DGP*DGP*DGP*DCP*DTP*DG)-3'), DNA (5'-D(*DTP*DCP*DAP*DGP*DCP*DCP*DCP*DAP*DTP*DAP*DAP*DAP*DTP*DCP*DAP*DTP*DAP*DGP*DAP*DG)-3'), Homeobox protein extradenticle, ...
Authors:Aggarwal, A.K, Passner, J.M, Jain, R.
Deposit date:2007-09-04
Release date:2008-02-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Functional specificity of a Hox protein mediated by the recognition of minor groove structure
Cell(Cambridge,Mass.), 131, 2007
6WC2
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BU of 6wc2 by Molmil
Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex
Descriptor: Homeobox protein Nkx-2.5, MEF2 Chimera,Myocyte-specific enhancer factor 2B,Myocyte-specific enhancer factor 2A, Myocardin Enhancer DNA
Authors:Lei, X, Chen, L.
Deposit date:2020-03-29
Release date:2020-07-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface.
J.Mol.Biol., 432, 2020
6WC5
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BU of 6wc5 by Molmil
Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex
Descriptor: Homeobox protein Nkx-2.5, Myocardin enhancer DNA, Myocyte-specific enhancer factor 2B
Authors:Chen, L, Lei, X.
Deposit date:2020-03-29
Release date:2020-07-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface.
J.Mol.Biol., 432, 2020
8SPS
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BU of 8sps by Molmil
High resolution structure of ESRRB nucleosome bound OCT4 at site a and site b
Descriptor: DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ...
Authors:Lian, T, Guan, R, Bai, Y.
Deposit date:2023-05-03
Release date:2023-06-28
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural mechanism of LIN28B nucleosome targeting by OCT4.
Mol.Cell, 83, 2023
8SPU
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BU of 8spu by Molmil
Structure of ESRRB nucleosome bound OCT4 at site c
Descriptor: DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ...
Authors:Lian, T, Guan, R, Bai, Y.
Deposit date:2023-05-03
Release date:2023-06-28
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural mechanism of LIN28B nucleosome targeting by OCT4.
Mol.Cell, 83, 2023
2R5Z
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BU of 2r5z by Molmil
Structure of Scr/Exd complex bound to a DNA sequence derived from the fkh gene
Descriptor: DNA (5'-D(*DAP*DCP*DTP*DCP*DTP*DAP*DAP*DGP*DAP*DTP*DTP*DAP*DAP*DTP*DCP*DGP*DGP*DCP*DTP*DG)-3'), DNA (5'-D(*DTP*DCP*DAP*DGP*DCP*DCP*DGP*DAP*DTP*DTP*DAP*DAP*DTP*DCP*DTP*DTP*DAP*DGP*DAP*DG)-3'), Homeobox protein extradenticle, ...
Authors:Aggarwal, A.K, Passner, J.M, Jain, R.
Deposit date:2007-09-04
Release date:2008-02-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Functional specificity of a Hox protein mediated by the recognition of minor groove structure
Cell(Cambridge,Mass.), 131, 2007
4UUS
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BU of 4uus by Molmil
CRYSTAL STRUCTURE OF A UBX-EXD-DNA COMPLEX INCLUDING THE UBDA MOTIF
Descriptor: 5'-D(*AP*CP*GP*TP*GP*AP*TP*TP*TP*AP*TP*GP*GP*CP*G)-3', 5'-D(*GP*TP*CP*GP*CP*CP*AP*TP*AP*AP*AP*TP*CP*AP*C)-3', HOMEOTIC PROTEIN EXTRADENTICLE, ...
Authors:Foos, N, Mate, M.J, Ortiz-Lombardia, M.
Deposit date:2014-07-31
Release date:2015-02-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A Flexible Extension of the Drosophila Ultrabithorax Homeodomain Defines a Novel Hox/Pbc Interaction Mode.
Structure, 23, 2015
6T90
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BU of 6t90 by Molmil
OCT4-SOX2-bound nucleosome - SHL-6
Descriptor: DNA (146-MER), Green fluorescent protein,POU domain, class 5, ...
Authors:Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H.
Deposit date:2019-10-25
Release date:2020-05-06
Last modified:2020-07-08
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
2XSD
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BU of 2xsd by Molmil
Crystal Structure of the dimeric Oct-6 (Pou3f1) POU domain bound to palindromic MORE DNA
Descriptor: 1,2-ETHANEDIOL, 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*AP)-3', 5'-D(*CP*CP*TP*CP*AP*TP*GP*CP*AP*TP*AP)-3', ...
Authors:Jauch, R, Choo, S.H, Ng, C.K.L, Kolatkar, P.R.
Deposit date:2010-09-28
Release date:2010-10-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.049 Å)
Cite:Crystal Structure of the Dimeric Oct6 (POU3F1) POU Domain Bound to Palindromic More DNA.
Proteins, 79, 2011
3L1P
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BU of 3l1p by Molmil
POU protein:DNA complex
Descriptor: DNA (5'-D(*AP*TP*CP*CP*AP*TP*TP*TP*GP*CP*CP*TP*TP*TP*CP*AP*AP*AP*TP*GP*TP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*AP*CP*AP*TP*TP*TP*GP*AP*AP*AP*GP*GP*CP*AP*AP*AP*TP*GP*GP*A)-3'), POU domain, ...
Authors:Vahokoski, J, Groves, M.R, Pogenberg, V, Wilmanns, M.
Deposit date:2009-12-14
Release date:2010-12-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A unique Oct4 interface is crucial for reprogramming to pluripotency
Nat.Cell Biol., 15, 2013
5EGO
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BU of 5ego by Molmil
HOXB13-MEIS1 heterodimer bound to methylated DNA
Descriptor: DNA (5'-D(*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ...
Authors:Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J.
Deposit date:2015-10-27
Release date:2016-11-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Science, 356, 2017
8G87
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BU of 8g87 by Molmil
Human Oct4 bound to nucleosome with human nMatn1 sequence (focused refinement of Oct4 bound region)
Descriptor: POU domain, class 5, transcription factor 1, ...
Authors:Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M.
Deposit date:2023-02-17
Release date:2023-03-22
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (8.1 Å)
Cite:Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
8G8E
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BU of 8g8e by Molmil
Human Oct4 bound to nucleosome with human LIN28B sequence
Descriptor: LIN28B DNA (32-MER), POU domain, class 5, ...
Authors:Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M.
Deposit date:2023-02-17
Release date:2023-03-22
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
8G8B
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BU of 8g8b by Molmil
Nucleosome with human nMatn1 sequence in complex with Human Oct4
Descriptor: Histone H2A, Histone H2B, Histone H3, ...
Authors:Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M.
Deposit date:2023-02-17
Release date:2023-03-22
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
8G88
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BU of 8g88 by Molmil
Human Oct4 bound to nucleosome with human nMatn1 sequence
Descriptor: Histone H2A, Histone H2B, Histone H3, ...
Authors:Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M.
Deposit date:2023-02-17
Release date:2023-03-22
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
8G8G
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BU of 8g8g by Molmil
Interaction of H3 tail in LIN28B nucleosome with Oct4
Descriptor: Histone H2A, Histone H2B, Histone H3, ...
Authors:Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M.
Deposit date:2023-02-17
Release date:2023-03-22
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
1S7E
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BU of 1s7e by Molmil
Solution structure of HNF-6
Descriptor: Hepatocyte nuclear factor 6
Authors:Liao, X, Sheng, W.
Deposit date:2004-01-29
Release date:2004-12-28
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure of the hepatocyte nuclear factor 6alpha and its interaction with DNA.
J.Biol.Chem., 279, 2004
5EG0
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BU of 5eg0 by Molmil
HOXB13-MEIS1 heterodimer bound to DNA
Descriptor: DNA (5'-D(*CP*CP*TP*CP*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*CP*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ...
Authors:Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J.
Deposit date:2015-10-26
Release date:2016-11-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:Molecular basis of recognition of two distinct DNA sequences by a single transcription factor
To Be Published
1O4X
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BU of 1o4x by Molmil
TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
Descriptor: 5'-D(*CP*AP*TP*TP*AP*GP*CP*AP*TP*GP*AP*CP*AP*AP*AP*GP*AP*CP*A)-3', 5'-D(*TP*GP*TP*CP*TP*TP*TP*GP*TP*CP*AP*TP*GP*CP*TP*AP*AP*TP*G)-3', Transcription factor SOX-2, ...
Authors:Clore, G.M, Williams, D.C.
Deposit date:2003-07-17
Release date:2004-01-27
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex.
J.Biol.Chem., 279, 2004
1OCT
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BU of 1oct by Molmil
CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA RECOGNITION WITH TETHERED DNA-BINDING MODULES
Descriptor: DNA (5'-D(*AP*CP*CP*TP*TP*AP*TP*TP*TP*GP*CP*AP*TP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*AP*TP*GP*CP*AP*AP*AP*TP*AP*AP*GP*G)-3'), PROTEIN (OCT-1 POU DOMAIN)
Authors:Klemm, J.D, Rould, M.A, Aurora, R, Herr, W, Pabo, C.O.
Deposit date:1994-05-09
Release date:1994-08-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules.
Cell(Cambridge,Mass.), 77, 1994
1AU7
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BU of 1au7 by Molmil
PIT-1 MUTANT/DNA COMPLEX
Descriptor: CONSENSUS DNA 25-MER, DNA (5'-D(*CP*TP*TP*CP*CP*TP*CP*AP*TP*GP*TP*AP*TP*AP*TP*AP*C P*AP*TP*GP*AP*GP* GP*A)-3'), PROTEIN PIT-1
Authors:Jacobson, E.M, Li, P, Leon-Del-Rio, A, Rosenfeld, M.G, Aggarwal, A.K.
Deposit date:1997-09-12
Release date:1998-01-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility.
Genes Dev., 11, 1997

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