2XSD
 
 | | Crystal Structure of the dimeric Oct-6 (Pou3f1) POU domain bound to palindromic MORE DNA | | Descriptor: | 1,2-ETHANEDIOL, 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*AP)-3', 5'-D(*CP*CP*TP*CP*AP*TP*GP*CP*AP*TP*AP)-3', ... | | Authors: | Jauch, R, Choo, S.H, Ng, C.K.L, Kolatkar, P.R. | | Deposit date: | 2010-09-28 | | Release date: | 2010-10-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.049 Å) | | Cite: | Crystal Structure of the Dimeric Oct6 (POU3F1) POU Domain Bound to Palindromic More DNA.
Proteins, 79, 2011
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3L1P
 | | POU protein:DNA complex | | Descriptor: | DNA (5'-D(*AP*TP*CP*CP*AP*TP*TP*TP*GP*CP*CP*TP*TP*TP*CP*AP*AP*AP*TP*GP*TP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*AP*CP*AP*TP*TP*TP*GP*AP*AP*AP*GP*GP*CP*AP*AP*AP*TP*GP*GP*A)-3'), POU domain, ... | | Authors: | Vahokoski, J, Groves, M.R, Pogenberg, V, Wilmanns, M. | | Deposit date: | 2009-12-14 | | Release date: | 2010-12-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | A unique Oct4 interface is crucial for reprogramming to pluripotency
Nat.Cell Biol., 15, 2013
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4XRS
 | | Heterodimeric complex of transcription factors MEIS1 and DLX3 on specific DNA | | Descriptor: | DNA (5'-D(P*AP*CP*AP*AP*TP*TP*AP*TP*CP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*CP*AP*AP*TP*TP*AP*TP*CP*CP*TP*GP*TP*CP*AP*A)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*GP*AP*TP*AP*AP*TP*TP*GP*TP*T)-3'), ... | | Authors: | Jorma, A, Yin, Y, Nitta, K.R, Dave, K, Enge, M, Kivioja, T, Popov, A, Morgunova, E, Taipale, J. | | Deposit date: | 2015-01-21 | | Release date: | 2015-11-04 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | DNA-dependent formation of transcription factor pairs alters their binding specificity.
Nature, 527, 2015
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6WC5
 | | Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex | | Descriptor: | Homeobox protein Nkx-2.5, Myocardin enhancer DNA, Myocyte-specific enhancer factor 2B | | Authors: | Chen, L, Lei, X. | | Deposit date: | 2020-03-29 | | Release date: | 2020-07-22 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface.
J.Mol.Biol., 432, 2020
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6WC2
 | | Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex | | Descriptor: | Homeobox protein Nkx-2.5, MEF2 Chimera,Myocyte-specific enhancer factor 2B,Myocyte-specific enhancer factor 2A, Myocardin Enhancer DNA | | Authors: | Lei, X, Chen, L. | | Deposit date: | 2020-03-29 | | Release date: | 2020-07-22 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface.
J.Mol.Biol., 432, 2020
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5NO6
 | | TEAD4-HOXB13 complex bound to DNA | | Descriptor: | DNA, Homeobox protein Hox-B13, Transcriptional enhancer factor TEF-3 | | Authors: | Morgunova, E, Jolma, A, Yin, Y, Popov, A, Taipale, J. | | Deposit date: | 2017-04-11 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.88 Å) | | Cite: | TEAD4-HOXB13 complex bound to DNA
To Be Published
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4S0H
 | | TBX5 DB, NKX2.5 HD, ANF DNA Complex | | Descriptor: | 5'-D(*CP*CP*AP*CP*TP*TP*CP*AP*AP*AP*GP*GP*TP*GP*TP*GP*AP*GP*A)-3', 5'-D(*TP*CP*TP*CP*AP*CP*AP*CP*CP*TP*TP*TP*GP*AP*AP*GP*TP*GP*G)-3', Homeobox protein Nkx-2.5, ... | | Authors: | Pradhan, L. | | Deposit date: | 2014-12-31 | | Release date: | 2015-12-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.817 Å) | | Cite: | Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5.
Biochemistry, 55, 2016
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1S7E
 | | Solution structure of HNF-6 | | Descriptor: | Hepatocyte nuclear factor 6 | | Authors: | Liao, X, Sheng, W. | | Deposit date: | 2004-01-29 | | Release date: | 2004-12-28 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure of the hepatocyte nuclear factor 6alpha and its interaction with DNA.
J.Biol.Chem., 279, 2004
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6T90
 | | OCT4-SOX2-bound nucleosome - SHL-6 | | Descriptor: | DNA (146-MER), Green fluorescent protein,POU domain, class 5, ... | | Authors: | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | | Deposit date: | 2019-10-25 | | Release date: | 2020-05-06 | | Last modified: | 2020-07-08 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
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8G87
 | | Human Oct4 bound to nucleosome with human nMatn1 sequence (focused refinement of Oct4 bound region) | | Descriptor: | POU domain, class 5, transcription factor 1, ... | | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | | Deposit date: | 2023-02-17 | | Release date: | 2023-03-22 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (8.1 Å) | | Cite: | Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
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8G88
 | | Human Oct4 bound to nucleosome with human nMatn1 sequence | | Descriptor: | Histone H2A, Histone H2B, Histone H3, ... | | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | | Deposit date: | 2023-02-17 | | Release date: | 2023-03-22 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
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8G8B
 | | Nucleosome with human nMatn1 sequence in complex with Human Oct4 | | Descriptor: | Histone H2A, Histone H2B, Histone H3, ... | | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | | Deposit date: | 2023-02-17 | | Release date: | 2023-03-22 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
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8G8E
 | | Human Oct4 bound to nucleosome with human LIN28B sequence | | Descriptor: | LIN28B DNA (32-MER), POU domain, class 5, ... | | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | | Deposit date: | 2023-02-17 | | Release date: | 2023-03-22 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
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8G8G
 | | Interaction of H3 tail in LIN28B nucleosome with Oct4 | | Descriptor: | Histone H2A, Histone H2B, Histone H3, ... | | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | | Deposit date: | 2023-02-17 | | Release date: | 2023-03-22 | | Last modified: | 2023-12-13 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
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3D1N
 | | Structure of human Brn-5 transcription factor in complex with corticotrophin-releasing hormone gene promoter | | Descriptor: | 5'-D(*DAP*DGP*DCP*DAP*DTP*DAP*DAP*DAP*DTP*DAP*DAP*DTP*DAP*DA)-3', 5'-D(*DTP*DTP*DAP*DTP*DTP*DAP*DTP*DTP*DTP*DAP*DTP*DGP*DCP*DT)-3', POU domain, ... | | Authors: | Pereira, J.H, Ha, S.C, Kim, S.-H. | | Deposit date: | 2008-05-06 | | Release date: | 2009-05-26 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Structure of human Brn-5 transcription factor in complex with CRH gene promoter.
J.Struct.Biol., 167, 2009
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5FLV
 | | Crystal structure of NKX2-5 and TBX5 bound to the Nppa promoter region | | Descriptor: | 5'-D(*AP*CP*CP*AP*CP*TP*TP*CP*AP*AP*AP*GP*GP*TP *GP*TP*GP*AP*GP*AP*AP*G)-3', 5'-D(*TP*CP*TP*TP*CP*TP*CP*AP*CP*AP*CP*CP*TP*TP *TP*GP*AP*AP*GP*TP*GP*G)-3', HOMEOBOX PROTEIN NKX-2.5, ... | | Authors: | Stirnimann, C.U, Glatt, S, Mueller, C.W. | | Deposit date: | 2015-10-28 | | Release date: | 2016-02-10 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.005 Å) | | Cite: | Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.
Cell(Cambridge,Mass.), 164, 2016
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5EGO
 | | HOXB13-MEIS1 heterodimer bound to methylated DNA | | Descriptor: | DNA (5'-D(*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ... | | Authors: | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | | Deposit date: | 2015-10-27 | | Release date: | 2016-11-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Science, 356, 2017
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5EG0
 | | HOXB13-MEIS1 heterodimer bound to DNA | | Descriptor: | DNA (5'-D(*CP*CP*TP*CP*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*CP*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ... | | Authors: | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | | Deposit date: | 2015-10-26 | | Release date: | 2016-11-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.101 Å) | | Cite: | Molecular basis of recognition of two distinct DNA sequences by a single transcription factor
To Be Published
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1MH3
 | | maltose binding-a1 homeodomain protein chimera, crystal form I | | Descriptor: | maltose binding-a1 homeodomain protein chimera | | Authors: | Ke, A, Wolberger, C. | | Deposit date: | 2002-08-19 | | Release date: | 2002-09-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera
Protein Sci., 12, 2003
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1MNM
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1MH4
 | | maltose binding-a1 homeodomain protein chimera, crystal form II | | Descriptor: | maltose binding-a1 homeodomain protein chimera | | Authors: | Ke, A, Wolberger, C. | | Deposit date: | 2002-08-19 | | Release date: | 2002-09-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera
Protein Sci., 12, 2003
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1O4X
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1B8I
 | | STRUCTURE OF THE HOMEOTIC UBX/EXD/DNA TERNARY COMPLEX | | Descriptor: | DNA (5'-D(*AP*CP*GP*TP*GP*AP*TP*TP*TP*AP*TP*GP*GP*CP*G)-3'), DNA (5'-D(*GP*TP*CP*GP*CP*CP*AP*TP*AP*AP*AP*TP*CP*AP*C)-3'), PROTEIN (HOMEOBOX PROTEIN EXTRADENTICLE), ... | | Authors: | Passner, J.M, Ryoo, H.-D, Shen, L, Mann, R.S, Aggarwal, A.K. | | Deposit date: | 1999-02-01 | | Release date: | 1999-04-12 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex.
Nature, 397, 1999
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1OCT
 | | CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA RECOGNITION WITH TETHERED DNA-BINDING MODULES | | Descriptor: | DNA (5'-D(*AP*CP*CP*TP*TP*AP*TP*TP*TP*GP*CP*AP*TP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*AP*TP*GP*CP*AP*AP*AP*TP*AP*AP*GP*G)-3'), PROTEIN (OCT-1 POU DOMAIN) | | Authors: | Klemm, J.D, Rould, M.A, Aurora, R, Herr, W, Pabo, C.O. | | Deposit date: | 1994-05-09 | | Release date: | 1994-08-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules.
Cell(Cambridge,Mass.), 77, 1994
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1GT0
 | | Crystal structure of a POU/HMG/DNA ternary complex | | Descriptor: | 5'-D(*AP*TP*CP*CP*CP*AP*TP*TP*AP*GP* CP*AP*TP*CP*CP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3', 5'-D(*TP*TP*CP*TP*TP*TP*GP*TP*TP*TP* GP*GP*AP* TP*GP*CP*TP*AP*AP*TP*GP*GP*GP*A)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1, ... | | Authors: | Remenyi, A, Wilmanns, M. | | Deposit date: | 2002-01-09 | | Release date: | 2003-01-30 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure of a POU/Hmg/DNA Ternary Complex Suggests Differential Assembly of Oct4 and Sox2 on Two Enhancers
Genes Dev., 17, 2003
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