HOXB13-MEIS1 heterodimer bound to methylated DNA

Summary for 5EGO

DescriptorHomeobox protein Meis1, DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), ... (5 entities in total)
Functional Keywordstranscription factor, heterodimer, complex, bound to dna, transcription
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  O00470 Q92826
Total number of polymer chains4
Total molecular weight25456.13
Morgunova, E.,Yin, Y.,Jolma, A.,Popov, A.,Taipale, J. (deposition date: 2015-10-27, release date: 2016-11-09, Last modification date: 2017-05-17)
Primary citation
Yin, Y.,Morgunova, E.,Jolma, A.,Kaasinen, E.,Sahu, B.,Khund-Sayeed, S.,Das, P.K.,Kivioja, T.,Dave, K.,Zhong, F.,Nitta, K.R.,Taipale, M.,Popov, A.,Ginno, P.A.,Domcke, S.,Yan, J.,Schubeler, D.,Vinson, C.,Taipale, J.
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Science, 356:-, 2017
PubMed: 28473536 (PDB entries with the same primary citation)
DOI: 10.1126/science.aaj2239
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2618 1.7% 9.3% 3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-28