5EGO

HOXB13-MEIS1 heterodimer bound to methylated DNA

Summary for 5EGO

• Entry DOI: 10.2210/pdb5ego/pdb
• Descriptor: Homeobox protein Meis1, DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), ... (5 entities in total)
• Functional Keywords: transcription factor, heterodimer, complex, bound to dna, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : O00470 Q92826
• Total number of polymer chains: 4
• Total formula weight: 25456.13

Authors

Morgunova, E.,Yin, Y.,Jolma, A.,Popov, A.,Taipale, J. (deposition date: 2015-10-27, release date: 2016-11-09, Last modification date: 2024-01-10)

• Primary citation: Yin, Y.,Morgunova, E.,Jolma, A.,Kaasinen, E.,Sahu, B.,Khund-Sayeed, S.,Das, P.K.,Kivioja, T.,Dave, K.,Zhong, F.,Nitta, K.R.,Taipale, M.,Popov, A.,Ginno, P.A.,Domcke, S.,Yan, J.,Schubeler, D.,Vinson, C.,Taipale, J.; Impact of cytosine methylation on DNA binding specificities of human transcription factors.; Science, 356:-, 2017; PubMed: 28473536; DOI: 10.1126/science.aaj2239

Experimental method

X-RAY DIFFRACTION (2.54 Å)