5EGO

HOXB13-MEIS1 heterodimer bound to methylated DNA

Summary for 5EGO

DescriptorHomeobox protein Meis1, DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), ... (5 entities in total)
Functional Keywordstranscription factor, heterodimer, complex, bound to dna, transcription
Biological sourceHomo sapiens (Human)
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Cellular locationNucleus  O00470 Q92826
Total number of polymer chains4
Total molecular weight25456.13
Authors
Morgunova, E.,Yin, Y.,Jolma, A.,Popov, A.,Taipale, J. (deposition date: 2015-10-27, release date: 2016-11-09, Last modification date: 2017-05-17)
Primary citation
Yin, Y.,Morgunova, E.,Jolma, A.,Kaasinen, E.,Sahu, B.,Khund-Sayeed, S.,Das, P.K.,Kivioja, T.,Dave, K.,Zhong, F.,Nitta, K.R.,Taipale, M.,Popov, A.,Ginno, P.A.,Domcke, S.,Yan, J.,Schubeler, D.,Vinson, C.,Taipale, J.
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Science, 356:-, 2017
PubMed: 28473536 (PDB entries with the same primary citation)
DOI: 10.1126/science.aaj2239
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.54 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2618 1.7% 9.3% 3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
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PDB entries from 2020-10-28