6WC2

Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex

Summary for 6WC2

Entry DOI	10.2210/pdb6wc2/pdb
Descriptor	MEF2 Chimera,Myocyte-specific enhancer factor 2B,Myocyte-specific enhancer factor 2A, Myocardin Enhancer DNA, Homeobox protein Nkx-2.5, ... (5 entities in total)
Functional Keywords	transcription factor, dna binding protein, cardiogenesis, carcinogenesis, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	15
Total formula weight	129719.01
Authors	Lei, X.,Chen, L. (deposition date: 2020-03-29, release date: 2020-07-22, Last modification date: 2023-10-18)
Primary citation	Lei, X.,Zhao, J.,Sagendorf, J.M.,Rajashekar, N.,Xu, J.,Dantas Machado, A.C.,Sen, C.,Rohs, R.,Feng, P.,Chen, L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J.Mol.Biol., 432:5499-5508, 2020 Cited by PubMed: 32681840 DOI: 10.1016/j.jmb.2020.07.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation