6WC2

Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, I... (A, B, C, D, I...)	MEF2 Chimera,Myocyte-specific enhancer factor 2B,Myocyte-specific enhancer factor 2A	polymer	95	11343.2	6	UniProt (Q02078) UniProt (Q02080) Pfam (PF00319)	Homo sapiens (Human)	Serum response factor-like protein 1,RSRFR2,Serum response factor-like protein 2,Serum response factor-like protein 1
2	E, G, K (E, G, K)	Myocardin Enhancer DNA	polymer	21	6445.2	3		synthetic construct
3	F, H, L (F, H, L)	Myocardin Enhancer DNA	polymer	21	6436.2	3		synthetic construct
4	M, N, O (M, N, O)	Homeobox protein Nkx-2.5	polymer	61	7671.9	3	UniProt (P52952) Pfam (PF00046)	Homo sapiens (Human)	Cardiac-specific homeobox,Homeobox protein CSX,Homeobox protein NK-2 homolog E
5	AA, BA, CA, DA, P... (L, M, N, O, A...)	water	water		18.0	445	Chemie (HOH)

Sequence modifications

A, B, C, D, I, J: 1 - 72 (UniProt: Q02078)
A, B, C, D, I, J: 73 - 91 (UniProt: Q02080)
A, B, C, D, I, J: 92 - 95 (UniProt: Q02078)
M, N, O: 137 - 197 (UniProt: P52952)

PDB	External Database	Details
Ser 193	Cys 193	conflict

Contents of the asymmetric unit

Polymers	Number of chains	15
	Total formula weight	129719.0
All*	Total formula weight	129719.0

*Water molecules are not included.