6WC2

Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
A	0003677	molecular_function	DNA binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046983	molecular_function	protein dimerization activity
B	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
B	0003677	molecular_function	DNA binding
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046983	molecular_function	protein dimerization activity
C	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
C	0003677	molecular_function	DNA binding
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046983	molecular_function	protein dimerization activity
D	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
D	0003677	molecular_function	DNA binding
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046983	molecular_function	protein dimerization activity
I	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
I	0003677	molecular_function	DNA binding
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046983	molecular_function	protein dimerization activity
J	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
J	0003677	molecular_function	DNA binding
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0046983	molecular_function	protein dimerization activity
M	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
M	0003677	molecular_function	DNA binding
M	0006355	biological_process	regulation of DNA-templated transcription
N	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
N	0003677	molecular_function	DNA binding
N	0006355	biological_process	regulation of DNA-templated transcription
O	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
O	0003677	molecular_function	DNA binding
O	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. LAsvLkLTstQVKIWFqNrryksK

Chain	Residue	Details
M	LEU171-LYS194

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site_id	PS00350
Number of Residues	55
Details	MADS_BOX_1 MADS-box domain signature. RkKiqitrImDernRqvTFtKRKfgLmKKAyELSvLcdceIaLIIfnssnkLfqY

Chain	Residue	Details
A	ARG3-TYR57

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	177
Details	DNA_BIND: Homeobox => ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:22849347, ECO:0000269|PubMed:26926761

Chain	Residue	Details
M	ARG138-ARG197
N	ARG138-ARG197
O	ARG138-ARG197
D	SER59
I	SER59
J	SER59

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