6WC2

Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
A	0003677	molecular_function	DNA binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046983	molecular_function	protein dimerization activity
B	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
B	0003677	molecular_function	DNA binding
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046983	molecular_function	protein dimerization activity
C	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
C	0003677	molecular_function	DNA binding
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046983	molecular_function	protein dimerization activity
D	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
D	0003677	molecular_function	DNA binding
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046983	molecular_function	protein dimerization activity
I	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
I	0003677	molecular_function	DNA binding
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046983	molecular_function	protein dimerization activity
J	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
J	0003677	molecular_function	DNA binding
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0046983	molecular_function	protein dimerization activity
M	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
M	0003677	molecular_function	DNA binding
M	0006355	biological_process	regulation of DNA-templated transcription
N	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
N	0003677	molecular_function	DNA binding
N	0006355	biological_process	regulation of DNA-templated transcription
O	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
O	0003677	molecular_function	DNA binding
O	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. LAsvLkLTstQVKIWFqNrryksK

Chain	Residue	Details
M	LEU171-LYS194

---

site_id	PS00350
Number of Residues	55
Details	MADS_BOX_1 MADS-box domain signature. RkKiqitrImDernRqvTFtKRKfgLmKKAyELSvLcdceIaLIIfnssnkLfqY

Chain	Residue	Details
A	ARG3-TYR57

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	270
Details	Domain: {"description":"MADS-box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00251","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	168
Details	DNA binding: {"description":"Mef2-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine; by CK2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---