8GAF
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![BU of 8gaf by Molmil](/molmil-images/mine/8gaf) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | Descriptor: | Cas11, Cas5, Cas7, ... | Authors: | Hu, C, Nam, K.H, Ke, A. | Deposit date: | 2023-02-22 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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8GAM
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![BU of 8gam by Molmil](/molmil-images/mine/8gam) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | Descriptor: | Cas11, Cas5, Cas7, ... | Authors: | Hu, C, Nam, K.H, Ke, A. | Deposit date: | 2023-02-23 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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3UNI
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![BU of 3uni by Molmil](/molmil-images/mine/3uni) | Crystal Structure of Bovine Milk Xanthine Dehydrogenase with NADH Bound | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-HYDROXYBENZOIC ACID, CALCIUM ION, ... | Authors: | Eger, B.T, Okamoto, K, Nishino, T, Pai, E.F. | Deposit date: | 2011-11-15 | Release date: | 2012-05-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Protein conformational gating of enzymatic activity in xanthine oxidoreductase. J.Am.Chem.Soc., 134, 2012
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1HDI
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![BU of 1hdi by Molmil](/molmil-images/mine/1hdi) | Pig muscle 3-PHOSPHOGLYCERATE KINASE complexed with 3-PG and MgADP. | Descriptor: | 3-PHOSPHOGLYCERIC ACID, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... | Authors: | Szilagyi, A.N, Ghosh, M, Garman, E, Vas, M. | Deposit date: | 2000-11-16 | Release date: | 2001-02-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A 1.8 A resolution structure of pig muscle 3-phosphoglycerate kinase with bound MgADP and 3-phosphoglycerate in open conformation: new insight into the role of the nucleotide in domain closure. J. Mol. Biol., 306, 2001
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8Y0W
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![BU of 8y0w by Molmil](/molmil-images/mine/8y0w) | |
1GOX
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![BU of 1gox by Molmil](/molmil-images/mine/1gox) | |
3UNA
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![BU of 3una by Molmil](/molmil-images/mine/3una) | Crystal Structure of Bovine Milk Xanthine Dehydrogenase with NAD Bound | Descriptor: | 2-HYDROXYBENZOIC ACID, CALCIUM ION, CARBONATE ION, ... | Authors: | Eger, B.T, Okamoto, K, Nishino, T, Pai, E.F. | Deposit date: | 2011-11-15 | Release date: | 2012-05-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Protein conformational gating of enzymatic activity in xanthine oxidoreductase. J.Am.Chem.Soc., 134, 2012
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1PZE
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![BU of 1pze by Molmil](/molmil-images/mine/1pze) | T.gondii LDH1 apo form | Descriptor: | lactate dehydrogenase | Authors: | Kavanagh, K.L, Elling, R.A, Wilson, D.K. | Deposit date: | 2003-07-10 | Release date: | 2004-02-24 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use. Biochemistry, 43, 2004
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1PZG
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![BU of 1pzg by Molmil](/molmil-images/mine/1pzg) | |
1GPM
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![BU of 1gpm by Molmil](/molmil-images/mine/1gpm) | ESCHERICHIA COLI GMP SYNTHETASE COMPLEXED WITH AMP AND PYROPHOSPHATE | Descriptor: | ADENOSINE MONOPHOSPHATE, CITRIC ACID, GMP SYNTHETASE, ... | Authors: | Tesmer, J.J.G. | Deposit date: | 1995-04-04 | Release date: | 1996-01-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. Nat.Struct.Biol., 3, 1996
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3VKG
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![BU of 3vkg by Molmil](/molmil-images/mine/3vkg) | X-ray structure of an MTBD truncation mutant of dynein motor domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Dynein heavy chain, cytoplasmic, ... | Authors: | Kon, T, Oyama, T, Shimo-Kon, R, Suto, K, Kurisu, G. | Deposit date: | 2011-11-16 | Release date: | 2012-03-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | The 2.8 A crystal structure of the dynein motor domain Nature, 484, 2012
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1BOF
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![BU of 1bof by Molmil](/molmil-images/mine/1bof) | GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM | Descriptor: | GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Coleman, D.E, Sprang, S.R. | Deposit date: | 1998-08-04 | Release date: | 1999-01-06 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of the G protein Gi alpha 1 complexed with GDP and Mg2+: a crystallographic titration experiment. Biochemistry, 37, 1998
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1THY
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![BU of 1thy by Molmil](/molmil-images/mine/1thy) | |
5BXV
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![BU of 5bxv by Molmil](/molmil-images/mine/5bxv) | eIF4E complex | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1 | Authors: | Sekiyama, N, Arthanari, H, Papdopoulos, E, Rodriguez-Mias, R.A, Wagner, G, Leger-Abraham, M. | Deposit date: | 2015-06-09 | Release date: | 2015-07-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1. Proc.Natl.Acad.Sci.USA, 112, 2015
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1TMU
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![BU of 1tmu by Molmil](/molmil-images/mine/1tmu) | |
1ZL1
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![BU of 1zl1 by Molmil](/molmil-images/mine/1zl1) | Crystal structure of the complex of signalling protein from sheep (SPS-40) with a designed peptide Trp-His-Trp reveals significance of Asn79 and Trp191 in the complex formation | Descriptor: | Chitinase-3 like protein 1, TRP-HIS-TRP peptide, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Ethayathulla, A.S, Srivastava, D.B, Singh, N, Kumar, J, Somvanshi, R.K, Sharma, S, Dey, S, Singh, T.P. | Deposit date: | 2005-05-05 | Release date: | 2005-05-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structure of the complex of signalling protein from sheep (SPS-40) with a designed peptide Trp-His-Trp reveals significance of Asn79 and Trp191 in the complex formation TO BE PUBLISHED
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4BES
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![BU of 4bes by Molmil](/molmil-images/mine/4bes) | Crystal structure of the Legionella pneumophila FIC domain-containing effector AnkX protein in complex with cytidine monophosphate and phosphocholine | Descriptor: | CYTIDINE-5'-MONOPHOSPHATE, PHOSPHOCHOLINE, PHOSPHOCHOLINE TRANSFERASE ANKX, ... | Authors: | Campanacci, V, Mukherjee, S, Roy, C.R, Cherfils, J. | Deposit date: | 2013-03-12 | Release date: | 2013-04-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Structure of the Legionella Effector Ankx Reveals the Mechanism of Phosphocholine Transfer by the Fic Domain. Embo J., 32, 2013
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8OMU
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![BU of 8omu by Molmil](/molmil-images/mine/8omu) | |
1MLC
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![BU of 1mlc by Molmil](/molmil-images/mine/1mlc) | MONOCLONAL ANTIBODY FAB D44.1 RAISED AGAINST CHICKEN EGG-WHITE LYSOZYME COMPLEXED WITH LYSOZYME | Descriptor: | HEN EGG WHITE LYSOZYME, IGG1-KAPPA D44.1 FAB (HEAVY CHAIN), IGG1-KAPPA D44.1 FAB (LIGHT CHAIN) | Authors: | Braden, B.C, Souchon, H, Eisele, J.-L, Bentley, G.A, Bhat, T.N, Navaza, J, Poljak, R.J. | Deposit date: | 1995-03-10 | Release date: | 1995-06-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Three-dimensional structures of the free and the antigen-complexed Fab from monoclonal anti-lysozyme antibody D44.1. J.Mol.Biol., 243, 1994
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7MDC
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![BU of 7mdc by Molmil](/molmil-images/mine/7mdc) | Full-length wildtype ClbP inhibited by hexanoyl-D-asparagine boronic acid | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-hexadec-9-enoate, Beta-lactamase, CHLORIDE ION, ... | Authors: | Velilla, J.A, Volpe, M.R, Gaudet, R. | Deposit date: | 2021-04-03 | Release date: | 2022-09-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A small molecule inhibitor prevents gut bacterial genotoxin production. Nat.Chem.Biol., 19, 2023
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8TO0
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![BU of 8to0 by Molmil](/molmil-images/mine/8to0) | 48-nm repeating structure of doublets from mouse sperm flagella | Descriptor: | Cilia- and flagella- associated protein 210, Cilia- and flagella-associated protein 107, Cilia- and flagella-associated protein 141, ... | Authors: | Chen, Z, Shiozak, M, Hass, K.M, Skinner, W, Zhao, S, Guo, C, Polacco, B.J, Yu, Z, Krogan, N.J, Kaake, R.M, Vale, R.D, Agard, D.A. | Deposit date: | 2023-08-02 | Release date: | 2023-11-01 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Cell, 186, 2023
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1LYW
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![BU of 1lyw by Molmil](/molmil-images/mine/1lyw) | CATHEPSIN D AT PH 7.5 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CATHEPSIN D | Authors: | Lee, A.Y, Gulnik, S.V, Erickson, J.W. | Deposit date: | 1998-06-30 | Release date: | 1999-07-22 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Conformational switching in an aspartic proteinase. Nat.Struct.Biol., 5, 1998
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8B37
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![BU of 8b37 by Molmil](/molmil-images/mine/8b37) | Crystal structure of Pyrobaculum aerophilum potassium-independent proton pumping membrane integral pyrophosphatase in complex with imidodiphosphate and magnesium, and with bound sulphate | Descriptor: | IMIDODIPHOSPHORIC ACID, K(+)-insensitive pyrophosphate-energized proton pump, MAGNESIUM ION, ... | Authors: | Strauss, J, Wilkinson, C, Vidilaseris, K, Ribeiro, O, Liu, J, Hillier, J, Malinen, A, Gehl, B, Jeuken, L.C, Pearson, A.R, Goldman, A. | Deposit date: | 2022-09-16 | Release date: | 2024-01-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.84 Å) | Cite: | Functional and structural asymmetry suggest a unifying principle for catalysis in membrane-bound pyrophosphatases. Embo Rep., 25, 2024
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8BW9
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![BU of 8bw9 by Molmil](/molmil-images/mine/8bw9) | Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP | Descriptor: | Connector enhancer of KSR protein CNK, Dual specificity mitogen-activated protein kinase kinase dSOR1, KSR, ... | Authors: | Maisonneuve, P, Fronzes, R, Sicheri, F. | Deposit date: | 2022-12-06 | Release date: | 2024-02-21 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction. Nat.Struct.Mol.Biol., 31, 2024
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1IM6
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![BU of 1im6 by Molmil](/molmil-images/mine/1im6) | |