8GAM

Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications

Summary for 8GAM

• Entry DOI: 10.2210/pdb8gam/pdb
• EMDB information: 29900
• Descriptor: Cas7, Phage associated protein, Cas11, ... (7 entities in total)
• Functional Keywords: crispr, type i-c, cascade, anti-crispr, hydrolase-rna-dna complex, hydrolase/rna/dna
• Biological source: Neisseria lactamica; More
• Total number of polymer chains: 15
• Total formula weight: 432691.69

Authors

Hu, C.,Nam, K.H.,Ke, A. (deposition date: 2023-02-23, release date: 2024-03-06)

• Primary citation: Hu, C.,Myers, M.T.,Zhou, X.,Hou, Z.,Lozen, M.L.,Nam, K.H.,Zhang, Y.,Ke, A.; Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications.; Mol.Cell, 84:463-475.e5, 2024; PubMed: 38242128; DOI: 10.1016/j.molcel.2023.12.034

Experimental method

ELECTRON MICROSCOPY (3.46 Å)