PDB: 9904 resultsInfo pagesStatus searchChemie searchBIRD

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6SF6	Crystal structure of the mAb 15A in complex with COMP-epitope P6 Descriptor: COMP-reactive monoclonal antibody 15A Fab fragment, heavy chain, light chain, ... Authors: Dobritzsch, D, Ge, C, Holmdahl, R. Deposit date: 2019-08-01 Release date: 2020-06-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Antibodies to cartilage oligomeric matrix protein in vivo are pathogenic and clinically relevant in rheumatoid arthritis To Be Published
8DB4	Crystal structure of the peanut allergen Ara h 2 bound by two neutralizing antibodies 22S1 and 13T1 Descriptor: 1,2-ETHANEDIOL, 13T1 Heavy chain, 13T1 Light chain, ... Authors: Min, J, Pedersen, L.C. Deposit date: 2022-06-14 Release date: 2023-01-25 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Immunotherapy-induced neutralizing antibodies disrupt allergen binding and sustain allergen tolerance in peanut allergy. J.Clin.Invest., 133, 2023
8H08	SARS-CoV-2 BA.1 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Descriptor: 10-5B H chain, 10-5B L chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Wang, X, Wang, Z. Deposit date: 2022-09-28 Release date: 2023-05-31 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants. Nat Commun, 14, 2023
8H07	SARS-CoV-2 BA.4 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Descriptor: 10-5B H chain, 10-5B L chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Wang, X, Wang, Z. Deposit date: 2022-09-28 Release date: 2023-05-31 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants. Nat Commun, 14, 2023
7UPL	SARS-Cov2 Omicron varient S protein structure in complex with neutralizing monoclonal antibody 002-S21F2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... Authors: Patel, A, Ortlund, E. Deposit date: 2022-04-15 Release date: 2022-08-10 Last modified: 2023-02-22 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody. Sci Adv, 8, 2022
8GBX	Crystal structure of PC39-50I, an anti-HIV broadly neutralizing antibody Descriptor: PC39-50I Fab heavy chain, PC39-50I Fab light chain Authors: Murrell, S, Omorodion, O, Wilson, I.A. Deposit date: 2023-02-28 Release date: 2023-06-07 Last modified: 2023-07-12 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies. Plos Pathog., 19, 2023
8GBY	Crystal structure of PC39-50E, an anti-HIV broadly neutralizing antibody Descriptor: GLYCEROL, PC39-50E Fab heavy chain, PC39-50E Fab light chain Authors: Murrell, S, Omorodion, O, Wilson, I.A. Deposit date: 2023-02-28 Release date: 2023-06-07 Last modified: 2023-07-12 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies. Plos Pathog., 19, 2023
8GBW	Crystal structure of PC39-23D, an anti-HIV broadly neutralizing antibody Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PC39-23D Fab heavy chain, ... Authors: Murrell, S, Omorodion, O, Wilson, I.A. Deposit date: 2023-02-28 Release date: 2023-06-07 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies. Plos Pathog., 19, 2023
8GC0	Crystal structure of PC39-50L, an anti-HIV broadly neutralizing antibody Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PC39-50L Fab heavy chain, PC39-50L Fab light chain Authors: Murrell, S, Omorodion, O, Wilson, I.A. Deposit date: 2023-02-28 Release date: 2023-06-07 Last modified: 2023-07-12 Method: X-RAY DIFFRACTION (2.43 Å) Cite: Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies. Plos Pathog., 19, 2023
8GBV	Crystal structure of PC39-17A, an anti-HIV broadly neutralizing antibody Descriptor: 1,2-ETHANEDIOL, ACETATE ION, PC39-17A Fab heavy chain, ... Authors: Murrell, S, Omorodion, O, Wilson, I.A. Deposit date: 2023-02-28 Release date: 2023-06-07 Last modified: 2023-07-12 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies. Plos Pathog., 19, 2023
8GC1	Crystal structure of the unmutated common ancestor (UCA) of the PC39-1 anti-HIV broadly neutralizing antibody lineage Descriptor: PC39-1 UCA Fab heavy chain, PC39-1 UCA Fab light chain Authors: Murrell, S, Omorodion, O, Wilson, I.A. Deposit date: 2023-02-28 Release date: 2023-06-07 Last modified: 2023-07-12 Method: X-RAY DIFFRACTION (3.19 Å) Cite: Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies. Plos Pathog., 19, 2023
8GBZ	Crystal structure of PC39-55C, an anti-HIV broadly neutralizing antibody Descriptor: DI(HYDROXYETHYL)ETHER, PC39-55C Fab heavy chain, PC39-55C Fab light chain Authors: Murrell, S, Omorodion, O, Wilson, I.A. Deposit date: 2023-02-28 Release date: 2023-06-07 Last modified: 2023-07-12 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies. Plos Pathog., 19, 2023
2RCS	IMMUNOGLOBULIN 48G7 GERMLINE FAB-AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY Descriptor: IMMUNOGLOBULIN 48G7 GERMLINE FAB Authors: Wedemayer, G.J, Wang, L.H, Patten, P.A, Schultz, P.G, Stevens, R.C. Deposit date: 1997-05-14 Release date: 1997-11-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural insights into the evolution of an antibody combining site. Science, 276, 1997
1UM5	Catalytic Antibody 21H3 with alcohol substrate Descriptor: 1-PHENYLETHANOL, Antibody 21H3 H chain, Antibody 21H3 L chain Authors: Beuscher IV, A.E, Reuter, J, Olson, A.J, Romesberg, F.E, Schultz, P.G, Wirsching, P, Janda, K.D, Lerner, R.A, Stevens, R.C. Deposit date: 2003-09-23 Release date: 2004-10-05 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Studies of an Efficient Catalytic Antibody Operating by Ping-Pong and Induced Fit Mechanisms To be Published
6B3D	Crystal structure of anti-HIV antibody PGT128 in complex with a bacterially derived synthetic mimetic of Man9. Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... Authors: Murrell, S, Wilson, I.A. Deposit date: 2017-09-21 Release date: 2017-12-06 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.271 Å) Cite: Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity. Nat Commun, 8, 2017
6BFS	The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies Descriptor: Fab Heavy Chain, Fab light Chain, Granulocyte-macrophage colony-stimulating factor Authors: Dhagat, U, Hercus, T.R, Broughton, S.E, Nero, T.L, Lopez, A.F, Parker, M.W. Deposit date: 2017-10-26 Release date: 2018-09-12 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities. MAbs, 10, 2018
6EHV	scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery Descriptor: scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery Authors: Hargreaves, D. Deposit date: 2017-09-15 Release date: 2017-11-08 Last modified: 2019-10-16 Method: X-RAY DIFFRACTION (2.54 Å) Cite: scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery To Be Published
6MEK	Crystal structure of Hepatitis C virus envelope glycoprotein E2 core in complex with human antibodies HEPC3 and HEPC46 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, E2 GLYCOPROTEIN, ... Authors: Flyak, A.I, Bjorkman, P.J. Deposit date: 2018-09-06 Release date: 2018-11-21 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (3.1 Å) Cite: HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design. Cell Host Microbe, 24, 2018
6EHW	scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery Descriptor: scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery Authors: Hargreaves, D. Deposit date: 2017-09-15 Release date: 2017-11-08 Last modified: 2019-10-16 Method: X-RAY DIFFRACTION (2.19 Å) Cite: scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery To Be Published
7SI2	Crystal structure of neutralizing antibody 10-28 in complex with SARS-CoV-2 spike receptor binding domain (RBD) Descriptor: 10-28 Heavy Chain, 10-28 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Reddem, E.R, Shapiro, L. Deposit date: 2021-10-12 Release date: 2022-04-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.2 Å) Cite: An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Sci Transl Med, 14, 2022
7SD5	Crystallographic structure of neutralizing antibody 10-40 in complex with SARS-CoV-2 spike receptor binding domain Descriptor: 10-40 Heavy chain, 10-40 Light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Reddem, E.R, Casner, R.G, Shapiro, L. Deposit date: 2021-09-29 Release date: 2022-04-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.53 Å) Cite: An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Sci Transl Med, 14, 2022
8G4T	Vaccine-elicited human antibody 2C09 in complex with HIV-1 envelope trimer BG505 DS-SOSIP Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein BG505 DS-SOSIP gp120, ... Authors: Wang, S, Kwong, P.D. Deposit date: 2023-02-10 Release date: 2023-07-12 Last modified: 2023-07-26 Method: ELECTRON MICROSCOPY (2.81 Å) Cite: HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide. Cell Rep, 42, 2023
6BFQ	The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies Descriptor: Fab Heavy chain, Fab Light Chain, Granulocyte-macrophage colony-stimulating factor Authors: Dhagat, U, Hercus, T.R, Broughton, S.E, Nero, T.L, Lopez, A.F, Parker, M.W. Deposit date: 2017-10-26 Release date: 2018-09-12 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities. MAbs, 10, 2018
1XFP	Crystal structure of the CDR2 germline reversion mutant of cAb-Lys3 in complex with hen egg white lysozyme Descriptor: FORMIC ACID, Lysozyme C, heavy chain antibody Authors: De Genst, E, Handelberg, F, Van Meirhaeghe, A, Vynck, S, Loris, R, Wyns, L, Muyldermans, S. Deposit date: 2004-09-15 Release date: 2004-09-28 Last modified: 2013-02-06 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Chemical Basis for the Affinity Maturation of a Camel Single Domain Antibody J.Biol.Chem., 279, 2004
2YSS	Crystal structure of Humanized HYHEL-10 FV mutant(HQ39KW47Y)-HEN lysozyme complex Descriptor: ANTI-LYSOZYME ANTIBODY FV REGION, Lysozyme C Authors: Nakanishi, T, Tsumoto, K, Yokota, A, Kondo, H, Kumagai, I. Deposit date: 2007-04-03 Release date: 2008-04-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Critical contribution of VH-VL interaction to reshaping of an antibody: the case of humanization of anti-lysozyme antibody, HyHEL-10 Protein Sci., 17, 2008

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