6B3D
Crystal structure of anti-HIV antibody PGT128 in complex with a bacterially derived synthetic mimetic of Man9.
Summary for 6B3D
| Entry DOI | 10.2210/pdb6b3d/pdb |
| Descriptor | PGT128 Fab light chain, PGT128 Fab heavy chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose, ... (8 entities in total) |
| Functional Keywords | antibody, glycan, mannose, immune system |
| Biological source | Homo sapiens More |
| Total number of polymer chains | 2 |
| Total formula weight | 50006.56 |
| Authors | Murrell, S.,Wilson, I.A. (deposition date: 2017-09-21, release date: 2017-12-06, Last modification date: 2023-10-04) |
| Primary citation | Pantophlet, R.,Trattnig, N.,Murrell, S.,Lu, N.,Chau, D.,Rempel, C.,Wilson, I.A.,Kosma, P. Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity. Nat Commun, 8:1601-1601, 2017 Cited by PubMed: 29150603DOI: 10.1038/s41467-017-01640-y PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.271 Å) |
Structure validation
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