7UPL

SARS-Cov2 Omicron varient S protein structure in complex with neutralizing monoclonal antibody 002-S21F2

Summary for 7UPL

• Entry DOI: 10.2210/pdb7upl/pdb
• EMDB information: 26669
• Descriptor: Spike glycoprotein, mAB 002-S21F2 light chain, mAb 002-S21F2 heavy chain, ... (5 entities in total)
• Functional Keywords: sars-cov2, 6p, spike protein, immune complex, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 7
• Total formula weight: 573412.73

Authors

Patel, A.,Ortlund, E. (deposition date: 2022-04-15, release date: 2022-08-10, Last modification date: 2023-02-22)

• Primary citation: Kumar, S.,Patel, A.,Lai, L.,Chakravarthy, C.,Valanparambil, R.,Reddy, E.S.,Gottimukkala, K.,Davis-Gardner, M.E.,Edara, V.V.,Linderman, S.,Nayak, K.,Dixit, K.,Sharma, P.,Bajpai, P.,Singh, V.,Frank, F.,Cheedarla, N.,Verkerke, H.P.,Neish, A.S.,Roback, J.D.,Mantus, G.,Goel, P.K.,Rahi, M.,Davis, C.W.,Wrammert, J.,Godbole, S.,Henry, A.R.,Douek, D.C.,Suthar, M.S.,Ahmed, R.,Ortlund, E.,Sharma, A.,Murali-Krishna, K.,Chandele, A.; Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody.; Sci Adv, 8:eadd2032-eadd2032, 2022; PubMed: 36197988; DOI: 10.1126/sciadv.add2032

Experimental method

ELECTRON MICROSCOPY (4.1 Å)