8GBV

Crystal structure of PC39-17A, an anti-HIV broadly neutralizing antibody

Summary for 8GBV

• Entry DOI: 10.2210/pdb8gbv/pdb
• Related: 8GBW 8GBX 8GBY 8GBZ 8GC0 8GC1
• Descriptor: PC39-17A Fab heavy chain, PC39-17A Fab light chain, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: antibody, broadly neutralizing, hiv-1, v3 glycan, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 101181.80

Authors

Murrell, S.,Omorodion, O.,Wilson, I.A. (deposition date: 2023-02-28, release date: 2023-06-07, Last modification date: 2023-07-12)

• Primary citation: Joyce, C.,Murrell, S.,Murrell, B.,Omorodion, O.,Ver, L.S.,Carrico, N.,Bastidas, R.,Nedellec, R.,Bick, M.,Woehl, J.,Zhao, F.,Burns, A.,Barman, S.,Appel, M.,Ramos, A.,Wickramasinghe, L.,Eren, K.,Vollbrecht, T.,Smith, D.M.,Kosakovsky Pond, S.L.,McBride, R.,Worth, C.,Batista, F.,Sok, D.,Poignard, P.,Briney, B.,Wilson, I.A.,Landais, E.,Burton, D.R.; Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies.; Plos Pathog., 19:e1011416-e1011416, 2023; PubMed: 37384622; DOI: 10.1371/journal.ppat.1011416

Experimental method

X-RAY DIFFRACTION (2.08 Å)