6MEK
Crystal structure of Hepatitis C virus envelope glycoprotein E2 core in complex with human antibodies HEPC3 and HEPC46
Summary for 6MEK
| Entry DOI | 10.2210/pdb6mek/pdb |
| Related | 6MED 6MEE 6MEF 6MEG 6MEH 6MEI 6MEJ |
| Descriptor | E2 GLYCOPROTEIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, HEPC3 Heavy Chain, ... (10 entities in total) |
| Functional Keywords | hcv glycoprotein, broadly neutralizing antibodies, immune system |
| Biological source | Hepacivirus C More |
| Total number of polymer chains | 10 |
| Total formula weight | 249913.54 |
| Authors | Flyak, A.I.,Bjorkman, P.J. (deposition date: 2018-09-06, release date: 2018-11-21, Last modification date: 2020-07-29) |
| Primary citation | Flyak, A.I.,Ruiz, S.,Colbert, M.D.,Luong, T.,Crowe Jr., J.E.,Bailey, J.R.,Bjorkman, P.J. HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design. Cell Host Microbe, 24:703-716.e3, 2018 Cited by PubMed: 30439340DOI: 10.1016/j.chom.2018.10.009 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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