6MEK
Crystal structure of Hepatitis C virus envelope glycoprotein E2 core in complex with human antibodies HEPC3 and HEPC46
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | E2 GLYCOPROTEIN | polymer | 235 | 25837.1 | 2 | UniProt (H2FJ05) Pfam (PF01560) In PDB | Hepacivirus C | |
| 2 | B, H | HEPC3 Heavy Chain | polymer | 241 | 25759.8 | 2 | Homo sapiens | ||
| 3 | D, L | HEPC3 Light Chain | polymer | 214 | 23384.9 | 2 | Homo sapiens | ||
| 4 | E, G | HEPC46 Light Chain | polymer | 217 | 22938.2 | 2 | Homo sapiens | ||
| 5 | F, I | HEPC46 Heavy Chain | polymer | 230 | 24681.6 | 2 | Homo sapiens | ||
| 6 | J | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | Homo sapiens | ||
| 7 | K, P | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | Homo sapiens | ||
| 8 | M, N, Q | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | Homo sapiens | ||
| 9 | O | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G32708SB) | |||
| 10 | A, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | Homo sapiens |
Sequence modifications
A, C: 412 - 645 (UniProt: H2FJ05)
| PDB | External Database | Details |
|---|---|---|
| Asn 411 | - | expression tag |
| Asp 448 | Asn 448 | engineered mutation |
| Gly 482 | Gln 482 | linker |
| Ser 483 | Arg 483 | linker |
| Ser 484 | Pro 484 | linker |
| Gly 485 | Tyr 485 | linker |
| Asp 576 | Asn 576 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 245203.2 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 4267.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 249913.5 |
