6MEJ
Crystal structure of Hepatitis C virus envelope glycoprotein E2 ectodomain in complex with human antibodies HEPC3 and HEPC46
Summary for 6MEJ
Entry DOI | 10.2210/pdb6mej/pdb |
Related | 6MED 6MEE 6MEF 6MEG 6MEH 6MEI 6MEK |
Descriptor | antibody HEPC46 Heavy Chain, antibody HEPC46 Light Chain, E2 glycoprotein, ... (8 entities in total) |
Functional Keywords | hcv glycoprotein, broadly neutralizing antibodies, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 5 |
Total formula weight | 128078.35 |
Authors | Flyak, A.I.,Bjorkman, P.J. (deposition date: 2018-09-06, release date: 2018-11-21, Last modification date: 2023-10-11) |
Primary citation | Flyak, A.I.,Ruiz, S.,Colbert, M.D.,Luong, T.,Crowe Jr., J.E.,Bailey, J.R.,Bjorkman, P.J. HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design. Cell Host Microbe, 24:703-716.e3, 2018 Cited by PubMed: 30439340DOI: 10.1016/j.chom.2018.10.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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