6MEJ

Crystal structure of Hepatitis C virus envelope glycoprotein E2 ectodomain in complex with human antibodies HEPC3 and HEPC46

Summary for 6MEJ

Entry DOI	10.2210/pdb6mej/pdb
Related	6MED 6MEE 6MEF 6MEG 6MEH 6MEI 6MEK
Descriptor	antibody HEPC46 Heavy Chain, antibody HEPC46 Light Chain, E2 glycoprotein, ... (8 entities in total)
Functional Keywords	hcv glycoprotein, broadly neutralizing antibodies, immune system
Biological source	Homo sapiens More
Total number of polymer chains	5
Total formula weight	128078.35
Authors	Flyak, A.I.,Bjorkman, P.J. (deposition date: 2018-09-06, release date: 2018-11-21, Last modification date: 2023-10-11)
Primary citation	Flyak, A.I.,Ruiz, S.,Colbert, M.D.,Luong, T.,Crowe Jr., J.E.,Bailey, J.R.,Bjorkman, P.J. HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design. Cell Host Microbe, 24:703-716.e3, 2018 Cited by PubMed: 30439340 DOI: 10.1016/j.chom.2018.10.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation