1XFP

Crystal structure of the CDR2 germline reversion mutant of cAb-Lys3 in complex with hen egg white lysozyme

Summary for 1XFP

• Entry DOI: 10.2210/pdb1xfp/pdb
• Related: 1JTT
• Descriptor: heavy chain antibody, Lysozyme C, FORMIC ACID, ... (4 entities in total)
• Functional Keywords: beta sandwich, immunoglobulin fold, protein-protein heterocomplex, alpha-beta othogonal bundle, immune system-hydrolase complex, immune system/hydrolase
• Biological source: Camelus dromedarius (Arabian camel); More
• Cellular location: Secreted: P00698
• Total number of polymer chains: 2
• Total formula weight: 29829.81

Authors

De Genst, E.,Handelberg, F.,Van Meirhaeghe, A.,Vynck, S.,Loris, R.,Wyns, L.,Muyldermans, S. (deposition date: 2004-09-15, release date: 2004-09-28, Last modification date: 2013-02-06)

• Primary citation: De Genst, E.,Handelberg, F.,Van Meirhaeghe, A.,Vynck, S.,Loris, R.,Wyns, L.,Muyldermans, S.; Chemical Basis for the Affinity Maturation of a Camel Single Domain Antibody; J.Biol.Chem., 279:53593-53601, 2004; PubMed: 15383540; DOI: 10.1074/jbc.M407843200

Experimental method

X-RAY DIFFRACTION (1.5 Å)