1XFP

Crystal structure of the CDR2 germline reversion mutant of cAb-Lys3 in complex with hen egg white lysozyme

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0003796	molecular_function	lysozyme activity
L	0003824	molecular_function	catalytic activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005737	cellular_component	cytoplasm
L	0005783	cellular_component	endoplasmic reticulum
L	0005794	cellular_component	Golgi apparatus
L	0016231	molecular_function	beta-N-acetylglucosaminidase activity
L	0016787	molecular_function	hydrolase activity
L	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
L	0016998	biological_process	cell wall macromolecule catabolic process
L	0031640	biological_process	killing of cells of another organism
L	0042742	biological_process	defense response to bacterium
L	0042802	molecular_function	identical protein binding
L	0050829	biological_process	defense response to Gram-negative bacterium
L	0050830	biological_process	defense response to Gram-positive bacterium
L	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FMT L 402

Chain	Residue
L	ASN65
L	HOH454
L	ASP66
L	GLY67
L	ARG68
L	THR69
L	PRO70
L	SER72
L	HOH416
L	HOH421

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FMT A 403

Chain	Residue
A	ALA6
A	TYR94
A	TYR95
A	CYS96
A	GLY124
A	GLN125
A	GLY126
A	THR127
A	HOH426

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT L 404

Chain	Residue
A	SER105
A	HOH432
L	GLU35
L	VAL109
L	ALA110
L	HOH420
L	HOH426

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT L 405

Chain	Residue
A	GLN39
A	HOH455
L	TYR20
L	ARG21
L	HOH487

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT L 406

Chain	Residue
L	TYR20
L	LYS96
L	LYS97
L	SER100
L	HOH468

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT L 407

Chain	Residue
A	TYR106
L	ASN46
L	THR47

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT L 408

Chain	Residue
L	GLY4
L	ARG5
L	CYS6
L	GLU7
L	FMT409

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT L 409

Chain	Residue
A	ILE29
L	ARG5
L	FMT408

---

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
L	CYS76-CYS94

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Domain: {"description":"C-type lysozyme","evidences":[{"source":"PROSITE-ProRule","id":"PRU00680","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 132l

Chain	Residue	Details
L	GLU35
L	ASP52

---

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain

Residue

Details

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