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4Z1T	MIF in complex with 4-[(4-oxo-2-thioxo-1,3-thiazolan-3-yl)methyl]benzonitrile Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Cho, T.Y. Deposit date: 2015-03-27 Release date: 2016-09-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21, 2017
4Z15	MIF in complex with 3-(2-furylmethyl)-2-thioxo-1,3-thiazolan-4-one Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Cho, T.Y. Deposit date: 2015-03-26 Release date: 2016-09-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21, 2017
4Z1U	MIF in complex with 1-(4-methylphenyl)-3-phenylprop-2-yn-1-one Descriptor: GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION Authors: Cho, T.Y. Deposit date: 2015-03-27 Release date: 2016-09-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21, 2017
5BS9	Crystal structure of N109A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2015-06-01 Release date: 2015-09-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.98 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
5B4O	Crystal structure of Macrophage Migration Inhibitory Factor in complex with BTZO-14 Descriptor: 1,2-ETHANEDIOL, 2-pyridin-3-yl-1,3-benzothiazin-4-one, Macrophage migration inhibitory factor, ... Authors: Oki, H, Igaki, S, Moriya, Y, Hayano, Y, Habuka, N. Deposit date: 2016-04-07 Release date: 2016-04-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.37 Å) Cite: BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression Chem. Biol., 17, 2010
5BSJ	Crystal structure of S63A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2015-06-02 Release date: 2016-06-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of S63A mutant of human macrophage migration inhibitory factor To Be Published
5BSI	Crystal structure of Y36A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION Authors: Pantouris, G, Lolis, E. Deposit date: 2015-06-02 Release date: 2015-09-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
5BSC	Crystal structure of K66A mutant of human macrophage migration inhibitory factor Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor Authors: Pantouris, G, Lolis, E. Deposit date: 2015-06-01 Release date: 2015-09-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.89 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
6B1C	Macrophage Migration Inhibitory Factor in complex with a Naphthyridinone Inhibitor (4a) Descriptor: 2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-7-methyl-1,7-naphthyridin-8(7H)-one, Macrophage migration inhibitory factor, SULFATE ION Authors: Krimmer, S.G, Robertson, M.J, Jorgensen, W.L. Deposit date: 2017-09-18 Release date: 2018-01-03 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.163 Å) Cite: Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett, 8, 2017
6B2C	Macrophage Migration Inhibitory Factor in Complex with a Naphthyridinone Inhibitor (4b) Descriptor: Macrophage migration inhibitory factor, SULFATE ION, {2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-8-oxo-1,7-naphthyridin-7(8H)-yl}acetic acid Authors: Krimmer, S.G, Robertson, M.J, Jorgensen, W.L. Deposit date: 2017-09-19 Release date: 2018-01-03 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett, 8, 2017
6BG7	Crystal structure of G107A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2017-10-27 Release date: 2018-06-06 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.54 Å) Cite: Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74. Angew. Chem. Int. Ed. Engl., 57, 2018
6BG6	Crystal structure of S111A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2017-10-27 Release date: 2018-06-06 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74. Angew. Chem. Int. Ed. Engl., 57, 2018
6B1K	Macrophage Migration Inhibitory Factor in Complex with a Naphthyridinone Inhibitor (3a) Descriptor: 2-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-7-methyl-1,7-naphthyridin-8(7H)-one, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: Krimmer, S.G, Robertson, M.J, Jorgensen, W.L. Deposit date: 2017-09-18 Release date: 2018-01-03 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.17 Å) Cite: Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett, 8, 2017
6C5F	Human D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with the selective inhibitor 4-CPPC Descriptor: 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid, D-dopachrome decarboxylase Authors: Pantouris, G, Lolis, E.J. Deposit date: 2018-01-16 Release date: 2018-06-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor. Biochemistry, 57, 2018
6CBG	Macrophage Migration Inhibitory Factor in Complex with a Pyrazole Inhibitor (5) Descriptor: 3-(1H-pyrazol-4-yl)benzoic acid, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: Robertson, M.J, Krimmer, S.G, Jorgensen, W.L. Deposit date: 2018-02-02 Release date: 2018-04-04 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor. ChemMedChem, 13, 2018
6CBH	Macrophage Migration Inhibitory Factor in Complex with a Pyrazole Inhibitor (8m) Descriptor: 5-(3-fluoro-1H-pyrazol-4-yl)-2-[(naphthalen-2-yl)oxy]benzoic acid, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Robertson, M.J, Krimmer, S.G, Jorgensen, W.L. Deposit date: 2018-02-02 Release date: 2018-04-04 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor. ChemMedChem, 13, 2018
4NWR	Computationally Designed Two-Component Self-Assembling Tetrahedral Cage T33-28 Descriptor: Macrophage migration inhibitory factor-like protein, integron gene cassette protein Authors: McNamara, D.E, King, N.P, Bale, J.B, Sheffler, W, Baker, D, Yeates, T.O. Deposit date: 2013-12-06 Release date: 2014-05-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Accurate design of co-assembling multi-component protein nanomaterials. Nature, 510, 2014
6CBF	Macrophage Migration Inhibitory Factor in Complex with a Pyrazole Inhibitor (6a) Descriptor: 2-phenoxy-5-(1H-pyrazol-4-yl)benzoic acid, Macrophage migration inhibitory factor, SULFATE ION Authors: Robertson, M.J, Krimmer, S.G, Jorgensen, W.L. Deposit date: 2018-02-02 Release date: 2018-04-04 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor. ChemMedChem, 13, 2018
6CB5	Macrophage Migration Inhibitory Factor in complex with a Pyrazole Inhibitor (8g) Descriptor: 2-[(naphthalen-2-yl)oxy]-5-(1H-pyrazol-4-yl)benzoic acid, Macrophage migration inhibitory factor, SULFATE ION Authors: Krimmer, S.G, Robertson, M.J, Jorgensen, W.L. Deposit date: 2018-02-02 Release date: 2018-04-04 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor. ChemMedChem, 13, 2018
4P0H	Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with Dimethylformamide Descriptor: DIMETHYLFORMAMIDE, GLYCEROL, Macrophage migration inhibitory factor Authors: Pantouris, G, Lolis, E. Deposit date: 2014-02-21 Release date: 2014-04-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.93 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4OYQ	(6-isothiocyanatohexyl)benzene inhibitor complexed with Macrophage Migration Inhibitory Factor Descriptor: 6-isothiocyanatohexylbenzene, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: Spencer, E.S, Dale, E.J, Gommans, A.L, Vo, C.T, Rutledge, M.T, Nakatani, Y, Gamble, A.B, Smith, R.A.J, Wilbanks, S.M, Hampton, M.B, Tyndall, J.D.A. Deposit date: 2014-02-12 Release date: 2014-03-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: To be published To be published
6CUQ	Crystal structure of Macrophage migration inhibitory factor-like protein (EhMIF) from Entamoeba histolytica Descriptor: 1,2-ETHANEDIOL, Macrophage migration inhibitory factor-like protein Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-03-26 Release date: 2018-04-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Crystal structure of Macrophage migration inhibitory factor-like protein (EhMIF) from Entamoeba histolytica to be published
4OSF	4-(2-isothiocyanatoethyl)phenol inhibitor complexed with Macrophage Migration Inhibitory Factor Descriptor: CHLORIDE ION, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Spencer, E.S, Dale, E.J, Gommans, A.L, Vo, C.T, Rutledge, M.T, Nakatani, Y, Gamble, A.B, Smith, R.A.J, Wilbanks, S.M, Hampton, M.B, Tyndall, J.D.A. Deposit date: 2014-02-12 Release date: 2014-03-12 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor Eur.J.Med.Chem., 93, 2015
4P01	Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide Descriptor: CHLORIDE ION, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-02-19 Release date: 2014-03-19 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.07 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4P7M	Crystal structure of Plasmodium falciparum MIF in complex with 3-[(2-methyl-6-phenylpyridin-4-yl)oxy]phenol Descriptor: 3-[(2-methyl-6-phenylpyridin-4-yl)oxy]phenol, Macrophage migration inhibitory factor-like protein Authors: Pantouris, G, Lolis, E. Deposit date: 2014-03-27 Release date: 2014-10-15 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.02 Å) Cite: Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors. J.Med.Chem., 57, 2014

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