6C5F
Human D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with the selective inhibitor 4-CPPC
Summary for 6C5F
| Entry DOI | 10.2210/pdb6c5f/pdb |
| Descriptor | D-dopachrome decarboxylase, 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid (3 entities in total) |
| Functional Keywords | selective inhibitor, cytokine |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 3 |
| Total formula weight | 38067.80 |
| Authors | Pantouris, G.,Lolis, E.J. (deposition date: 2018-01-16, release date: 2018-06-13, Last modification date: 2023-10-04) |
| Primary citation | Pantouris, G.,Bucala, R.,Lolis, E.J. Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor. Biochemistry, 57:3599-3605, 2018 Cited by PubMed: 29847104DOI: 10.1021/acs.biochem.8b00344 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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