4A57
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2I6B
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![BU of 2i6b by Molmil](/molmil-images/mine/2i6b) | Human Adenosine Kinase in Complex with An Acetylinic Inhibitor | Descriptor: | 5-[4-(DIMETHYLAMINO)PHENYL]-6-[(6-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYNYL]PYRIMIDIN-4-AMINE, Adenosine kinase | Authors: | Muchmore, S.W. | Deposit date: | 2006-08-28 | Release date: | 2007-01-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes. J.Med.Chem., 49, 2006
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2H39
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![BU of 2h39 by Molmil](/molmil-images/mine/2h39) | Crystal Structure of an ADP-Glucose Phosphorylase from Arabidopsis thaliana with bound ADP-Glucose | Descriptor: | ADENOSINE-5'-DIPHOSPHATE-GLUCOSE, CHLORIDE ION, Probable galactose-1-phosphate uridyl transferase, ... | Authors: | McCoy, J.G, Wesenberg, G.E, Phillips Jr, G.N, Bitto, E, Bingman, C.A, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2006-05-22 | Release date: | 2006-06-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Crystal Structure of an ADP-Glucose Phosphorylase from Arabidopsis thaliana with bound ADP-Glucose To be Published
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5DYJ
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![BU of 5dyj by Molmil](/molmil-images/mine/5dyj) | Mysosin heavy chain kinase A catalytic domain mutant - D663A | Descriptor: | ADENOSINE MONOPHOSPHATE, GLYCEROL, Myosin heavy chain kinase A, ... | Authors: | van Staalduinen, L.M, Yang, Y, Jia, Z. | Deposit date: | 2015-09-24 | Release date: | 2016-06-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the Dictyostelium Myosin-II Heavy Chain Kinase A (MHCK-A) alpha-kinase domain apoenzyme reveals a novel autoinhibited conformation. Sci Rep, 6, 2016
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5IPP
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5KKG
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![BU of 5kkg by Molmil](/molmil-images/mine/5kkg) | Crystal structure of E72A mutant of ancestral protein ancMT of ADP-dependent sugar kinases family | Descriptor: | ADENOSINE MONOPHOSPHATE, GLYCEROL, IODIDE ION, ... | Authors: | Castro-Fernandez, V, Herrera-Morande, A, Zamora, R, Merino, F, Pereira, H.M, Brandao-Neto, J, Garratt, R, Guixe, V. | Deposit date: | 2016-06-21 | Release date: | 2017-07-26 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.608 Å) | Cite: | Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases. J. Biol. Chem., 292, 2017
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7ZDL
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7ZDK
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3I8V
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![BU of 3i8v by Molmil](/molmil-images/mine/3i8v) | Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone | Descriptor: | (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one, COBALT (II) ION, GLYCEROL, ... | Authors: | Cheng, R.K.Y, Crawley, L, Barker, J, Wood, M, Felicetti, B, Whittaker, M. | Deposit date: | 2009-07-10 | Release date: | 2009-07-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone To be Published
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1XSC
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![BU of 1xsc by Molmil](/molmil-images/mine/1xsc) | Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Bis(5'-nucleosyl)-tetraphosphatase | Authors: | Swarbrick, J.D, Buyya, S, Gunawardana, D, Gayler, K.R, McLennan, A.G, Gooley, P.R. | Deposit date: | 2004-10-18 | Release date: | 2004-12-21 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure and Substrate-binding Mechanism of Human Ap4A Hydrolase J.Biol.Chem., 280, 2005
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1XSA
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![BU of 1xsa by Molmil](/molmil-images/mine/1xsa) | Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) | Descriptor: | Bis(5'-nucleosyl)-tetraphosphatase | Authors: | Swarbrick, J.D, Buyya, S, Gunawardana, D, Gayler, K.R, McLennan, A.G, Gooley, P.R. | Deposit date: | 2004-10-18 | Release date: | 2004-12-21 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure and Substrate-binding Mechanism of Human Ap4A Hydrolase J.Biol.Chem., 280, 2005
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1RB0
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1XSB
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![BU of 1xsb by Molmil](/molmil-images/mine/1xsb) | Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP. No ATP restraints included | Descriptor: | Bis(5'-nucleosyl)-tetraphosphatase | Authors: | Swarbrick, J.D, Buyya, S, Gunawardana, D, Gayler, K.R, McLennan, A.G, Gooley, P.R. | Deposit date: | 2004-10-18 | Release date: | 2004-12-21 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure and Substrate-binding Mechanism of Human Ap4A Hydrolase J.Biol.Chem., 280, 2005
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3PBK
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7WJV
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![BU of 7wjv by Molmil](/molmil-images/mine/7wjv) | Crystal structure of human liver FBPase complexed with an covalent inhibitor | Descriptor: | 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ... | Authors: | Cao, H, Huang, Y, Ren, Y, Wan, J. | Deposit date: | 2022-01-08 | Release date: | 2022-07-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.724 Å) | Cite: | N -Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction. J.Med.Chem., 65, 2022
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1H4Q
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![BU of 1h4q by Molmil](/molmil-images/mine/1h4q) | Prolyl-tRNA synthetase from Thermus thermophilus complexed with tRNApro(CGG), ATP and prolinol | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, PROLYL-TRNA SYNTHETASE, PYRROLIDINE-2-CARBALDEHYDE, ... | Authors: | Yaremchuk, A, Tukalo, M, Cusack, S. | Deposit date: | 2001-05-13 | Release date: | 2001-06-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase J.Mol.Biol., 309, 2001
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3GT8
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![BU of 3gt8 by Molmil](/molmil-images/mine/3gt8) | Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP | Descriptor: | Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Jura, N, Endres, N.F, Engel, K, Deindl, S, Das, R, Lamers, M.H, Wemmer, D.E, Zhang, X, Kuriyan, J. | Deposit date: | 2009-03-27 | Release date: | 2009-07-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.955 Å) | Cite: | Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell(Cambridge,Mass.), 137, 2009
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1H4S
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![BU of 1h4s by Molmil](/molmil-images/mine/1h4s) | Prolyl-tRNA synthetase from Thermus thermophilus complexed with tRNApro(CGG) and a prolyl-adenylate analogue | Descriptor: | '5'-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE, PROLYL-TRNA SYNTHETASE, SULFATE ION, ... | Authors: | Yaremchuk, A, Tukalo, M, Cusack, S. | Deposit date: | 2001-05-14 | Release date: | 2001-06-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase J.Mol.Biol., 309, 2001
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1H4T
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4IKE
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![BU of 4ike by Molmil](/molmil-images/mine/4ike) | |
1H4V
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1VFX
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![BU of 1vfx by Molmil](/molmil-images/mine/1vfx) | Crystal Structure of the Kif1A Motor Domain Complexed With ADP-Mg-AlFx | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ... | Authors: | Nitta, R, Kikkawa, M, Okada, Y, Hirokawa, N. | Deposit date: | 2004-04-19 | Release date: | 2004-08-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | KIF1A Alternately Uses Two Loops to Bind Microtubules Science, 305, 2004
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1HC7
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![BU of 1hc7 by Molmil](/molmil-images/mine/1hc7) | Prolyl-tRNA synthetase from Thermus thermophilus | Descriptor: | PROLYL-TRNA SYNTHETASE, ZINC ION | Authors: | Yaremchuk, A, Tukalo, M, Cusack, S. | Deposit date: | 2001-04-26 | Release date: | 2001-06-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase J.Mol.Biol., 309, 2001
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1VFZ
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![BU of 1vfz by Molmil](/molmil-images/mine/1vfz) | Crystal Structure of the Kif1A Motor Domain Complexed With ADP-Mg-VO4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (Fusion protein consisting of Kinesin-like protein KIF1A, ... | Authors: | Nitta, R, Kikkawa, M, Okada, Y, Hirokawa, N. | Deposit date: | 2004-04-19 | Release date: | 2004-08-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | KIF1A Alternately Uses Two Loops to Bind Microtubules Science, 305, 2004
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3FBP
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![BU of 3fbp by Molmil](/molmil-images/mine/3fbp) | STRUCTURE REFINEMENT OF FRUCTOSE-1,6-BISPHOSPHATASE AND ITS FRUCTOSE 2,6-BISPHOSPHATE COMPLEX AT 2.8 ANGSTROMS RESOLUTION | Descriptor: | 2,6-di-O-phosphono-beta-D-fructofuranose, FRUCTOSE 1,6-BISPHOSPHATASE | Authors: | Ke, H, Thorpe, C.M, Seaton, B.A, Marcus, F, Lipscomb, W.N. | Deposit date: | 1990-06-07 | Release date: | 1992-04-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure refinement of fructose-1,6-bisphosphatase and its fructose 2,6-bisphosphate complex at 2.8 A resolution. J.Mol.Biol., 212, 1990
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