3GT8
Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP
Summary for 3GT8
Entry DOI | 10.2210/pdb3gt8/pdb |
Descriptor | Epidermal growth factor receptor, Unknown peptide, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total) |
Functional Keywords | inactive kinase, dimer, alternative splicing, anti-oncogene, atp-binding, cell cycle, cell membrane, disease mutation, disulfide bond, glycoprotein, isopeptide bond, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, ubl conjugation |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 5 |
Total formula weight | 153562.26 |
Authors | Jura, N.,Endres, N.F.,Engel, K.,Deindl, S.,Das, R.,Lamers, M.H.,Wemmer, D.E.,Zhang, X.,Kuriyan, J. (deposition date: 2009-03-27, release date: 2009-07-21, Last modification date: 2024-02-21) |
Primary citation | Jura, N.,Endres, N.F.,Engel, K.,Deindl, S.,Das, R.,Lamers, M.H.,Wemmer, D.E.,Zhang, X.,Kuriyan, J. Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell(Cambridge,Mass.), 137:1293-1307, 2009 Cited by PubMed: 19563760DOI: 10.1016/j.cell.2009.04.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.955 Å) |
Structure validation
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