3GT8
Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (B, A, C, D) | Epidermal growth factor receptor | polymer | 330 | 37621.5 | 4 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | E (X) | Unknown peptide | polymer | 11 | 954.2 | 1 | Homo sapiens (human) | ||
| 3 | F, H, J, L (B, A, C, D) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 4 | Chemie (ANP) | |||
| 4 | G, I, K, M (B, A, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | N, O, P, Q (B, A, C, D) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
B, A, C, D: 672 - 998 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 669 | - | expression tag |
| Ala 670 | - | expression tag |
| Met 671 | - | expression tag |
| Arg 924 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 151440.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2122.0 | |
| All* | Total formula weight | 153562.3 |
