English 日本語简体中文繁體中文 한국어

✖

Menu

RCSB PDB PDBe BMRB Adv. Search Search help

Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3GT8

Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ANP B 1

Chain	Residue
B	MG11
B	GLN767
B	LEU768
B	MET769
B	ASP813
B	ARG817
B	ASN818
B	LEU820
B	ASP831
B	SER696
B	GLY697
B	ALA698
B	PHE699
B	GLY700
B	VAL702
B	ALA719
B	LYS721

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 11

Chain	Residue
B	ANP1
B	ARG817
B	ASN818
B	ASP831

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ANP A 2

Chain	Residue
A	MG12
A	HOH30
A	HOH35
A	GLY695
A	SER696
A	GLY697
A	ALA698
A	PHE699
A	VAL702
A	LYS721
A	GLN767
A	MET769
A	CYS773
A	ASP813
A	ARG817
A	ASN818
A	LEU820
A	ASP831

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 12

Chain	Residue
A	ANP2
A	HOH29
A	ASN818
A	ASP831

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ANP C 3

Chain	Residue
C	MG13
C	HOH42
C	GLY695
C	SER696
C	GLY697
C	ALA698
C	PHE699
C	VAL702
C	LYS721
C	THR766
C	GLN767
C	MET769
C	CYS773
C	ASP813
C	ARG817
C	ASN818
C	LEU820
C	ASP831

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 13

Chain	Residue
C	ANP3
C	HOH41
C	ARG817
C	ASN818
C	ASP831

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ANP D 4

Chain	Residue
D	MG14
D	HOH38
D	GLY697
D	ALA698
D	GLY700
D	VAL702
D	LYS721
D	GLN767
D	MET769
D	CYS773
D	ASP813
D	ARG817
D	ASN818
D	LEU820
D	ASP831

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 14

Chain	Residue
D	ANP4
D	ASN818
D	ASP831

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	28
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK

Chain	Residue	Details
B	LEU694-LYS721

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV

Chain	Residue	Details
B	LEU809-VAL821

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10028

Chain	Residue	Details
B	ASP813
A	ASP813
C	ASP813
D	ASP813

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
B	LEU694
A	LEU694
C	LEU694
D	LEU694

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:17349580, ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2EB3, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:2ITN, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:3VJN, ECO:0007744\|PDB:3VJO, ECO:0007744\|PDB:4RIW, ECO:0007744\|PDB:4RIY, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
B	LYS721
A	LYS721
C	LYS721
D	LYS721

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:17349580, ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2EB3, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:2ITN, ECO:0007744\|PDB:2ITV, ECO:0007744\|PDB:2ITX, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:3VJN, ECO:0007744\|PDB:3VJO, ECO:0007744\|PDB:4RIW, ECO:0007744\|PDB:4RIX, ECO:0007744\|PDB:4RIY, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
B	THR766
A	THR766
C	THR766
D	THR766

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:17349580, ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2EB3, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:2ITN, ECO:0007744\|PDB:2ITV, ECO:0007744\|PDB:2ITX, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:3VJN, ECO:0007744\|PDB:4RIW, ECO:0007744\|PDB:4RIX, ECO:0007744\|PDB:4RIY, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
B	ASP831
A	ASP831
C	ASP831
D	ASP831

site_id	SWS_FT_FI6
Number of Residues	4
Details	SITE: Important for interaction with PIK3C2B

Chain	Residue	Details
B	TYR992
A	TYR992
C	TYR992
D	TYR992

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269\|PubMed:29192674

Chain	Residue	Details
B	LYS721
A	LYS721
C	LYS721
D	LYS721

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269\|PubMed:23774213

Chain	Residue	Details
B	TYR845
A	TYR845
C	TYR845
D	TYR845

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:16083266, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
B	SER967
A	SER967
C	SER967
D	SER967

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
B	SER971
A	SER971
C	SER971
D	SER971

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269\|PubMed:19563760, ECO:0007744\|PubMed:18669648

Chain	Residue	Details
B	TYR974
A	TYR974
C	TYR974
D	TYR974

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269\|PubMed:19563760, ECO:0000269\|PubMed:23774213

Chain	Residue	Details
B	TYR992
A	TYR992
C	TYR992
D	TYR992

site_id	SWS_FT_FI13
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:33996800

Chain	Residue	Details
B	LYS692
C	LYS713
C	LYS730
C	LYS843
D	LYS692
D	LYS713
D	LYS730
D	LYS843
B	LYS713
B	LYS730
B	LYS843
A	LYS692
A	LYS713
A	LYS730
A	LYS843
C	LYS692

site_id	SWS_FT_FI14
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144

Chain	Residue	Details
D	LYS905
D	LYS946
B	LYS905
B	LYS946
A	LYS905
A	LYS946
C	LYS905
C	LYS946

site_id	SWS_FT_FI15
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:33996800

Chain	Residue	Details
B	LYS733
B	LYS936
A	LYS733
A	LYS936
C	LYS733
C	LYS936
D	LYS733
D	LYS936

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ARG817
B	ASP813

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP813
A	ASN818
A	ALA815

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP813
C	ASN818
C	ALA815

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP813
D	ASN818
D	ALA815

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ARG817
A	ASP813

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ARG817
C	ASP813

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ARG817
D	ASP813

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP813
B	ALA815

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP813
A	ALA815

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP813
C	ALA815

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP813
D	ALA815

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP813
B	ASN818
B	ALA815

229183

PDB entries from 2024-12-18

PDB statistics

PDBj update info

Contact PDBj

numon