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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3GT8

Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ANP B 1

Chain	Residue
B	MG11
B	GLN767
B	LEU768
B	MET769
B	ASP813
B	ARG817
B	ASN818
B	LEU820
B	ASP831
B	SER696
B	GLY697
B	ALA698
B	PHE699
B	GLY700
B	VAL702
B	ALA719
B	LYS721

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 11

Chain	Residue
B	ANP1
B	ARG817
B	ASN818
B	ASP831

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ANP A 2

Chain	Residue
A	MG12
A	HOH30
A	HOH35
A	GLY695
A	SER696
A	GLY697
A	ALA698
A	PHE699
A	VAL702
A	LYS721
A	GLN767
A	MET769
A	CYS773
A	ASP813
A	ARG817
A	ASN818
A	LEU820
A	ASP831

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 12

Chain	Residue
A	ANP2
A	HOH29
A	ASN818
A	ASP831

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ANP C 3

Chain	Residue
C	MG13
C	HOH42
C	GLY695
C	SER696
C	GLY697
C	ALA698
C	PHE699
C	VAL702
C	LYS721
C	THR766
C	GLN767
C	MET769
C	CYS773
C	ASP813
C	ARG817
C	ASN818
C	LEU820
C	ASP831

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 13

Chain	Residue
C	ANP3
C	HOH41
C	ARG817
C	ASN818
C	ASP831

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ANP D 4

Chain	Residue
D	MG14
D	HOH38
D	GLY697
D	ALA698
D	GLY700
D	VAL702
D	LYS721
D	GLN767
D	MET769
D	CYS773
D	ASP813
D	ARG817
D	ASN818
D	LEU820
D	ASP831

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 14

Chain	Residue
D	ANP4
D	ASN818
D	ASP831

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	28
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK

Chain	Residue	Details
B	LEU694-LYS721

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV

Chain	Residue	Details
B	LEU809-VAL821

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10028

Chain	Residue	Details
B	ASP813
A	ASP813
C	ASP813
D	ASP813

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
B	LEU694
A	LEU694
C	LEU694
D	LEU694

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:17349580, ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2EB3, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:2ITN, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:3VJN, ECO:0007744\|PDB:3VJO, ECO:0007744\|PDB:4RIW, ECO:0007744\|PDB:4RIY, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
B	LYS721
A	LYS721
C	LYS721
D	LYS721

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:17349580, ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2EB3, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:2ITN, ECO:0007744\|PDB:2ITV, ECO:0007744\|PDB:2ITX, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:3VJN, ECO:0007744\|PDB:3VJO, ECO:0007744\|PDB:4RIW, ECO:0007744\|PDB:4RIX, ECO:0007744\|PDB:4RIY, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
B	THR766
A	THR766
C	THR766
D	THR766

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:17349580, ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2EB3, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:2ITN, ECO:0007744\|PDB:2ITV, ECO:0007744\|PDB:2ITX, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:3VJN, ECO:0007744\|PDB:4RIW, ECO:0007744\|PDB:4RIX, ECO:0007744\|PDB:4RIY, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
B	ASP831
A	ASP831
C	ASP831
D	ASP831

site_id	SWS_FT_FI6
Number of Residues	4
Details	SITE: Important for interaction with PIK3C2B

Chain	Residue	Details
B	TYR992
A	TYR992
C	TYR992
D	TYR992

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269\|PubMed:29192674

Chain	Residue	Details
B	LYS721
A	LYS721
C	LYS721
D	LYS721

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269\|PubMed:23774213

Chain	Residue	Details
B	TYR845
A	TYR845
C	TYR845
D	TYR845

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:16083266, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
B	SER967
A	SER967
C	SER967
D	SER967

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
B	SER971
A	SER971
C	SER971
D	SER971

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269\|PubMed:19563760, ECO:0007744\|PubMed:18669648

Chain	Residue	Details
B	TYR974
A	TYR974
C	TYR974
D	TYR974

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269\|PubMed:19563760, ECO:0000269\|PubMed:23774213

Chain	Residue	Details
B	TYR992
A	TYR992
C	TYR992
D	TYR992

site_id	SWS_FT_FI13
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:33996800

Chain	Residue	Details
B	LYS692
C	LYS713
C	LYS730
C	LYS843
D	LYS692
D	LYS713
D	LYS730
D	LYS843
B	LYS713
B	LYS730
B	LYS843
A	LYS692
A	LYS713
A	LYS730
A	LYS843
C	LYS692

site_id	SWS_FT_FI14
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144

Chain	Residue	Details
D	LYS905
D	LYS946
B	LYS905
B	LYS946
A	LYS905
A	LYS946
C	LYS905
C	LYS946

site_id	SWS_FT_FI15
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:33996800

Chain	Residue	Details
B	LYS733
B	LYS936
A	LYS733
A	LYS936
C	LYS733
C	LYS936
D	LYS733
D	LYS936

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ARG817
B	ASP813

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP813
A	ASN818
A	ALA815

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP813
C	ASN818
C	ALA815

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP813
D	ASN818
D	ALA815

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ARG817
A	ASP813

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ARG817
C	ASP813

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ARG817
D	ASP813

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP813
B	ALA815

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP813
A	ALA815

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP813
C	ALA815

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP813
D	ALA815

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP813
B	ASN818
B	ALA815

224572

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