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3GT8

Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
C0004672molecular_functionprotein kinase activity
C0004713molecular_functionprotein tyrosine kinase activity
C0005524molecular_functionATP binding
C0006468biological_processprotein phosphorylation
D0004672molecular_functionprotein kinase activity
D0004713molecular_functionprotein tyrosine kinase activity
D0005524molecular_functionATP binding
D0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE ANP B 1
ChainResidue
BMG11
BGLN767
BLEU768
BMET769
BASP813
BARG817
BASN818
BLEU820
BASP831
BSER696
BGLY697
BALA698
BPHE699
BGLY700
BVAL702
BALA719
BLYS721

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG B 11
ChainResidue
BANP1
BARG817
BASN818
BASP831

site_idAC3
Number of Residues18
DetailsBINDING SITE FOR RESIDUE ANP A 2
ChainResidue
AMG12
AHOH30
AHOH35
AGLY695
ASER696
AGLY697
AALA698
APHE699
AVAL702
ALYS721
AGLN767
AMET769
ACYS773
AASP813
AARG817
AASN818
ALEU820
AASP831

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 12
ChainResidue
AANP2
AHOH29
AASN818
AASP831

site_idAC5
Number of Residues18
DetailsBINDING SITE FOR RESIDUE ANP C 3
ChainResidue
CMG13
CHOH42
CGLY695
CSER696
CGLY697
CALA698
CPHE699
CVAL702
CLYS721
CTHR766
CGLN767
CMET769
CCYS773
CASP813
CARG817
CASN818
CLEU820
CASP831

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG C 13
ChainResidue
CANP3
CHOH41
CARG817
CASN818
CASP831

site_idAC7
Number of Residues15
DetailsBINDING SITE FOR RESIDUE ANP D 4
ChainResidue
DMG14
DHOH38
DGLY697
DALA698
DGLY700
DVAL702
DLYS721
DGLN767
DMET769
DCYS773
DASP813
DARG817
DASN818
DLEU820
DASP831

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG D 14
ChainResidue
DANP4
DASN818
DASP831

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues28
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK
ChainResidueDetails
BLEU694-LYS721

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV
ChainResidueDetails
BLEU809-VAL821

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
BASP813
AASP813
CASP813
DASP813

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
ChainResidueDetails
BLEU694
ALEU694
CLEU694
DLEU694

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
ChainResidueDetails
BLYS721
ALYS721
CLYS721
DLYS721

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
ChainResidueDetails
BTHR766
ATHR766
CTHR766
DTHR766

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
ChainResidueDetails
BASP831
AASP831
CASP831
DASP831

site_idSWS_FT_FI6
Number of Residues4
DetailsSITE: Important for interaction with PIK3C2B
ChainResidueDetails
BTYR992
ATYR992
CTYR992
DTYR992

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:29192674
ChainResidueDetails
BLYS721
ALYS721
CLYS721
DLYS721

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:23774213
ChainResidueDetails
BTYR845
ATYR845
CTYR845
DTYR845

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:16083266, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER967
ASER967
CSER967
DSER967

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
BSER971
ASER971
CSER971
DSER971

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19563760, ECO:0007744|PubMed:18669648
ChainResidueDetails
BTYR974
ATYR974
CTYR974
DTYR974

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19563760, ECO:0000269|PubMed:23774213
ChainResidueDetails
BTYR992
ATYR992
CTYR992
DTYR992

site_idSWS_FT_FI13
Number of Residues16
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800
ChainResidueDetails
BLYS692
CLYS713
CLYS730
CLYS843
DLYS692
DLYS713
DLYS730
DLYS843
BLYS713
BLYS730
BLYS843
ALYS692
ALYS713
ALYS730
ALYS843
CLYS692

site_idSWS_FT_FI14
Number of Residues12
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144
ChainResidueDetails
DLYS905
DLYS946
BLYS905
BLYS946
ALYS905
ALYS946
CLYS905
CLYS946

site_idSWS_FT_FI15
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33996800
ChainResidueDetails
BLYS733
BLYS936
ALYS733
ALYS936
CLYS733
CLYS936
DLYS733
DLYS936

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BARG817
BASP813

site_idCSA10
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP813
AASN818
AALA815

site_idCSA11
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP813
CASN818
CALA815

site_idCSA12
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DASP813
DASN818
DALA815

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AARG817
AASP813

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CARG817
CASP813

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DARG817
DASP813

site_idCSA5
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASP813
BALA815

site_idCSA6
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP813
AALA815

site_idCSA7
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP813
CALA815

site_idCSA8
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DASP813
DALA815

site_idCSA9
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASP813
BASN818
BALA815

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PDB entries from 2024-11-20

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