Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004713 | molecular_function | protein tyrosine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006468 | biological_process | protein phosphorylation |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004713 | molecular_function | protein tyrosine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006468 | biological_process | protein phosphorylation |
C | 0004672 | molecular_function | protein kinase activity |
C | 0004713 | molecular_function | protein tyrosine kinase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0006468 | biological_process | protein phosphorylation |
D | 0004672 | molecular_function | protein kinase activity |
D | 0004713 | molecular_function | protein tyrosine kinase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE ANP B 1 |
Chain | Residue |
B | MG11 |
B | GLN767 |
B | LEU768 |
B | MET769 |
B | ASP813 |
B | ARG817 |
B | ASN818 |
B | LEU820 |
B | ASP831 |
B | SER696 |
B | GLY697 |
B | ALA698 |
B | PHE699 |
B | GLY700 |
B | VAL702 |
B | ALA719 |
B | LYS721 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 11 |
Chain | Residue |
B | ANP1 |
B | ARG817 |
B | ASN818 |
B | ASP831 |
site_id | AC3 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE ANP A 2 |
Chain | Residue |
A | MG12 |
A | HOH30 |
A | HOH35 |
A | GLY695 |
A | SER696 |
A | GLY697 |
A | ALA698 |
A | PHE699 |
A | VAL702 |
A | LYS721 |
A | GLN767 |
A | MET769 |
A | CYS773 |
A | ASP813 |
A | ARG817 |
A | ASN818 |
A | LEU820 |
A | ASP831 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 12 |
Chain | Residue |
A | ANP2 |
A | HOH29 |
A | ASN818 |
A | ASP831 |
site_id | AC5 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE ANP C 3 |
Chain | Residue |
C | MG13 |
C | HOH42 |
C | GLY695 |
C | SER696 |
C | GLY697 |
C | ALA698 |
C | PHE699 |
C | VAL702 |
C | LYS721 |
C | THR766 |
C | GLN767 |
C | MET769 |
C | CYS773 |
C | ASP813 |
C | ARG817 |
C | ASN818 |
C | LEU820 |
C | ASP831 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG C 13 |
Chain | Residue |
C | ANP3 |
C | HOH41 |
C | ARG817 |
C | ASN818 |
C | ASP831 |
site_id | AC7 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE ANP D 4 |
Chain | Residue |
D | MG14 |
D | HOH38 |
D | GLY697 |
D | ALA698 |
D | GLY700 |
D | VAL702 |
D | LYS721 |
D | GLN767 |
D | MET769 |
D | CYS773 |
D | ASP813 |
D | ARG817 |
D | ASN818 |
D | LEU820 |
D | ASP831 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG D 14 |
Chain | Residue |
D | ANP4 |
D | ASN818 |
D | ASP831 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 28 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK |
Chain | Residue | Details |
B | LEU694-LYS721 | |
site_id | PS00109 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV |
Chain | Residue | Details |
B | LEU809-VAL821 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
B | ASP813 | |
A | ASP813 | |
C | ASP813 | |
D | ASP813 | |
Chain | Residue | Details |
B | LEU694 | |
A | LEU694 | |
C | LEU694 | |
D | LEU694 | |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 |
Chain | Residue | Details |
B | LYS721 | |
A | LYS721 | |
C | LYS721 | |
D | LYS721 | |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 |
Chain | Residue | Details |
B | THR766 | |
A | THR766 | |
C | THR766 | |
D | THR766 | |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 |
Chain | Residue | Details |
B | ASP831 | |
A | ASP831 | |
C | ASP831 | |
D | ASP831 | |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | SITE: Important for interaction with PIK3C2B |
Chain | Residue | Details |
B | TYR992 | |
A | TYR992 | |
C | TYR992 | |
D | TYR992 | |
Chain | Residue | Details |
B | LYS721 | |
A | LYS721 | |
C | LYS721 | |
D | LYS721 | |
Chain | Residue | Details |
B | TYR845 | |
A | TYR845 | |
C | TYR845 | |
D | TYR845 | |
Chain | Residue | Details |
B | SER967 | |
A | SER967 | |
C | SER967 | |
D | SER967 | |
Chain | Residue | Details |
B | SER971 | |
A | SER971 | |
C | SER971 | |
D | SER971 | |
Chain | Residue | Details |
B | TYR974 | |
A | TYR974 | |
C | TYR974 | |
D | TYR974 | |
Chain | Residue | Details |
B | TYR992 | |
A | TYR992 | |
C | TYR992 | |
D | TYR992 | |
Chain | Residue | Details |
B | LYS692 | |
C | LYS713 | |
C | LYS730 | |
C | LYS843 | |
D | LYS692 | |
D | LYS713 | |
D | LYS730 | |
D | LYS843 | |
B | LYS713 | |
B | LYS730 | |
B | LYS843 | |
A | LYS692 | |
A | LYS713 | |
A | LYS730 | |
A | LYS843 | |
C | LYS692 | |
site_id | SWS_FT_FI14 |
Number of Residues | 12 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144 |
Chain | Residue | Details |
D | LYS905 | |
D | LYS946 | |
B | LYS905 | |
B | LYS946 | |
A | LYS905 | |
A | LYS946 | |
C | LYS905 | |
C | LYS946 | |
site_id | SWS_FT_FI15 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33996800 |
Chain | Residue | Details |
B | LYS733 | |
B | LYS936 | |
A | LYS733 | |
A | LYS936 | |
C | LYS733 | |
C | LYS936 | |
D | LYS733 | |
D | LYS936 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | ARG817 | |
B | ASP813 | |
site_id | CSA10 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ASP813 | |
A | ASN818 | |
A | ALA815 | |
site_id | CSA11 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
C | ASP813 | |
C | ASN818 | |
C | ALA815 | |
site_id | CSA12 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
D | ASP813 | |
D | ASN818 | |
D | ALA815 | |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ARG817 | |
A | ASP813 | |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
C | ARG817 | |
C | ASP813 | |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
D | ARG817 | |
D | ASP813 | |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | ASP813 | |
B | ALA815 | |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ASP813 | |
A | ALA815 | |
site_id | CSA7 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
C | ASP813 | |
C | ALA815 | |
site_id | CSA8 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
D | ASP813 | |
D | ALA815 | |
site_id | CSA9 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | ASP813 | |
B | ASN818 | |
B | ALA815 | |