5D41
EGFR kinase domain in complex with mutant selective allosteric inhibitor
Summary for 5D41
Entry DOI | 10.2210/pdb5d41/pdb |
Descriptor | Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total) |
Functional Keywords | allosteric inhibitor, egfr, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 76859.60 |
Authors | Yun, C.-H.,Park, E.,Eck, M.J. (deposition date: 2015-08-07, release date: 2016-06-08, Last modification date: 2023-09-27) |
Primary citation | Jia, Y.,Yun, C.H.,Park, E.,Ercan, D.,Manuia, M.,Juarez, J.,Xu, C.,Rhee, K.,Chen, T.,Zhang, H.,Palakurthi, S.,Jang, J.,Lelais, G.,DiDonato, M.,Bursulaya, B.,Michellys, P.Y.,Epple, R.,Marsilje, T.H.,McNeill, M.,Lu, W.,Harris, J.,Bender, S.,Wong, K.K.,Janne, P.A.,Eck, M.J. Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature, 534:129-132, 2016 Cited by PubMed: 27251290DOI: 10.1038/nature17960 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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