4RIY
Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation
Summary for 4RIY
Entry DOI | 10.2210/pdb4riy/pdb |
Related | 4RIW 4RIX |
Descriptor | Receptor tyrosine-protein kinase erbB-3, Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total) |
Functional Keywords | receptor tyrosine kinase, pseudokinase, kinase, atp binding, membrane, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P21860 Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 4 |
Total formula weight | 153134.62 |
Authors | Littlefield, P.,Liu, L.,Jura, N. (deposition date: 2014-10-07, release date: 2014-12-10, Last modification date: 2023-09-20) |
Primary citation | Littlefield, P.,Liu, L.,Mysore, V.,Shan, Y.,Shaw, D.E.,Jura, N. Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations. Sci.Signal., 7:ra114-ra114, 2014 Cited by PubMed: 25468994DOI: 10.1126/scisignal.2005786 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.981 Å) |
Structure validation
Download full validation report