4RIY
Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Receptor tyrosine-protein kinase erbB-3 | polymer | 326 | 36418.1 | 2 | UniProt (P21860) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3 |
2 | B, D | Epidermal growth factor receptor | polymer | 345 | 39167.2 | 2 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
3 | A, C | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
4 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
5 | B, D | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) |
Sequence modifications
A, C: 679 - 1001 (UniProt: P21860)
B, D: 658 - 998 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 676 | - | expression tag |
Ala 677 | - | expression tag |
Gly 678 | - | expression tag |
Gly 909 | Glu 928 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 654 | - | expression tag |
Ala 655 | - | expression tag |
Met 656 | - | expression tag |
Gly 657 | - | expression tag |
Arg 924 | Val 948 | engineered mutation |
Ala 973 | Phe 997 | engineered mutation |
Ala 977 | Leu 1001 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 151170.6 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1964.0 | |
All* | Total formula weight | 153134.6 |