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4RIY

Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation

Summary for 4RIY
Entry DOI10.2210/pdb4riy/pdb
Related4RIW 4RIX
DescriptorReceptor tyrosine-protein kinase erbB-3, Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
Functional Keywordsreceptor tyrosine kinase, pseudokinase, kinase, atp binding, membrane, transferase
Biological sourceHomo sapiens (human)
More
Cellular locationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P21860
Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains4
Total formula weight153134.62
Authors
Littlefield, P.,Liu, L.,Jura, N. (deposition date: 2014-10-07, release date: 2014-12-10, Last modification date: 2023-09-20)
Primary citationLittlefield, P.,Liu, L.,Mysore, V.,Shan, Y.,Shaw, D.E.,Jura, N.
Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Sci.Signal., 7:ra114-ra114, 2014
Cited by
PubMed: 25468994
DOI: 10.1126/scisignal.2005786
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.981 Å)
Structure validation

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