2I6B
Human Adenosine Kinase in Complex with An Acetylinic Inhibitor
Summary for 2I6B
Entry DOI | 10.2210/pdb2i6b/pdb |
Related | 2I6A |
Descriptor | Adenosine kinase, 5-[4-(DIMETHYLAMINO)PHENYL]-6-[(6-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYNYL]PYRIMIDIN-4-AMINE (3 entities in total) |
Functional Keywords | protein-ligand complex, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 78311.39 |
Authors | Muchmore, S.W. (deposition date: 2006-08-28, release date: 2007-01-02, Last modification date: 2023-08-30) |
Primary citation | Muchmore, S.W.,Smith, R.A.,Stewart, A.O.,Cowart, M.D.,Gomtsyan, A.,Matulenko, M.A.,Yu, H.,Severin, J.M.,Bhagwat, S.S.,Lee, C.H.,Kowaluk, E.A.,Jarvis, M.F.,Jakob, C.L. Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes. J.Med.Chem., 49:6726-6731, 2006 Cited by PubMed: 17154503DOI: 10.1021/jm060189a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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