2I6B
Human Adenosine Kinase in Complex with An Acetylinic Inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004001 | molecular_function | adenosine kinase activity |
| A | 0004136 | molecular_function | deoxyadenosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006175 | biological_process | dATP biosynthetic process |
| A | 0006753 | biological_process | nucleoside phosphate metabolic process |
| A | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0032263 | biological_process | GMP salvage |
| A | 0034654 | biological_process | nucleobase-containing compound biosynthetic process |
| A | 0044209 | biological_process | AMP salvage |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0106383 | biological_process | dAMP salvage |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004001 | molecular_function | adenosine kinase activity |
| B | 0004136 | molecular_function | deoxyadenosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006144 | biological_process | purine nucleobase metabolic process |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006175 | biological_process | dATP biosynthetic process |
| B | 0006753 | biological_process | nucleoside phosphate metabolic process |
| B | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0032263 | biological_process | GMP salvage |
| B | 0034654 | biological_process | nucleobase-containing compound biosynthetic process |
| B | 0044209 | biological_process | AMP salvage |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0106383 | biological_process | dAMP salvage |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 89I A 500 |
| Chain | Residue |
| A | ASN14 |
| A | PHE201 |
| A | TYR206 |
| B | PHE205 |
| B | 89I500 |
| A | GLN38 |
| A | ILE39 |
| A | GLY64 |
| A | SER65 |
| A | ALA136 |
| A | LEU138 |
| A | PHE170 |
| A | THR173 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 89I B 500 |
| Chain | Residue |
| A | PHE205 |
| A | 89I500 |
| B | GLN38 |
| B | ILE39 |
| B | LEU40 |
| B | SER65 |
| B | LEU138 |
| B | PHE170 |
| B | TYR206 |
| B | HOH585 |
Functional Information from PROSITE/UniProt
| site_id | PS00584 |
| Number of Residues | 14 |
| Details | PFKB_KINASES_2 pfkB family of carbohydrate kinases signature 2. DTnGAGDafvGGFL |
| Chain | Residue | Details |
| A | ASP294-LEU307 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:9843365, ECO:0007744|PDB:1BX4 |
| Chain | Residue | Details |
| A | ASP300 | |
| B | ASP300 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9843365, ECO:0007744|PDB:1BX4 |
| Chain | Residue | Details |
| A | ASP18 | |
| B | GLN289 | |
| A | SER32 | |
| A | ASP130 | |
| A | ASN131 | |
| A | GLN289 | |
| B | ASP18 | |
| B | SER32 | |
| B | ASP130 | |
| B | ASN131 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:12112843 |
| Chain | Residue | Details |
| A | TYR60 | |
| B | TYR60 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1lio |
| Chain | Residue | Details |
| A | ASP300 | |
| A | ARG132 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1lio |
| Chain | Residue | Details |
| B | ASP300 | |
| B | ARG132 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1lio |
| Chain | Residue | Details |
| A | ALA298 | |
| A | ASP300 | |
| A | GLY297 | |
| A | GLY299 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1lio |
| Chain | Residue | Details |
| B | ALA298 | |
| B | ASP300 | |
| B | GLY297 | |
| B | GLY299 |
