2I6A

Human Adenosine Kinase in Complex With 5'-Deoxy-5-Iodotubercidin

Summary for 2I6A

Entry DOI	10.2210/pdb2i6a/pdb
Related	2I6B
Descriptor	Adenosine kinase, 7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE (3 entities in total)
Functional Keywords	protein-ligand complex, 5'-deoxy-5-iodotubercidin, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	156525.48
Authors	Muchmore, S.W. (deposition date: 2006-08-28, release date: 2007-01-02, Last modification date: 2024-02-21)
Primary citation	Muchmore, S.W.,Smith, R.A.,Stewart, A.O.,Cowart, M.D.,Gomtsyan, A.,Matulenko, M.A.,Yu, H.,Severin, J.M.,Bhagwat, S.S.,Lee, C.H.,Kowaluk, E.A.,Jarvis, M.F.,Jakob, C.L. Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes. J.Med.Chem., 49:6726-6731, 2006 Cited by PubMed: 17154503 DOI: 10.1021/jm060189a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation