4YZ6
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![BU of 4yz6 by Molmil](/molmil-images/mine/4yz6) | Crystal Structure of Myc3[44-238] from Arabidopsis in complex with Jaz1 peptide [200-221] | Descriptor: | Protein TIFY 10A, Transcription factor MYC3 | Authors: | Ke, J, Zhang, F, Brunzelle, J, Xu, H.E, Melcher, K, HE, S.Y. | Deposit date: | 2015-03-24 | Release date: | 2015-08-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. Nature, 525, 2015
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7W80
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![BU of 7w80 by Molmil](/molmil-images/mine/7w80) | Crystal Structure of the Heterodimeric HIF-2 in Complex with Antagonist Belzutifan | Descriptor: | 3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | Authors: | Ren, X, Diao, X, Zhuang, J, Wu, D. | Deposit date: | 2021-12-07 | Release date: | 2022-09-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.754 Å) | Cite: | Structural basis for the allosteric inhibition of hypoxia-inducible factor (HIF)-2 by belzutifan. Mol.Pharmacol., 2022
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4RQW
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![BU of 4rqw by Molmil](/molmil-images/mine/4rqw) | Crystal structure of Myc3 N-terminal JAZ-binding domain [44-238] from Arabidopsis | Descriptor: | CALCIUM ION, Transcription factor MYC3 | Authors: | Ke, J, Zhang, F, Zhou, X.E, Brunzelle, J, Zhou, M, Xu, H.E, Melcher, K, He, S.Y. | Deposit date: | 2014-11-05 | Release date: | 2015-08-12 | Last modified: | 2015-09-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. Nature, 525, 2015
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4RRU
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![BU of 4rru by Molmil](/molmil-images/mine/4rru) | Myc3 N-terminal JAZ-binding domain[5-242] from arabidopsis | Descriptor: | CALCIUM ION, Transcription factor MYC3 | Authors: | Ke, J, Zhang, F, Zhou, X.E, Brunzelle, J.S, Zhou, M, Xu, H.E, Melcher, K, He, S.Y. | Deposit date: | 2014-11-06 | Release date: | 2015-08-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. Nature, 525, 2015
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4RS9
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![BU of 4rs9 by Molmil](/molmil-images/mine/4rs9) | Structure of Myc3 N-terminal JAZ-binding domain [44-238] in complex with Jas motif of JAZ9 | Descriptor: | Protein TIFY 7, Transcription factor MYC3 | Authors: | Ke, J, Zhang, F, Zhou, X.E, Brunzelle, J.S, Zhou, M, Xu, H.E, Melcher, K, He, S.Y. | Deposit date: | 2014-11-07 | Release date: | 2015-08-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. Nature, 525, 2015
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4M4X
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![BU of 4m4x by Molmil](/molmil-images/mine/4m4x) | |
3AY5
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![BU of 3ay5 by Molmil](/molmil-images/mine/3ay5) | |
5T0Q
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![BU of 5t0q by Molmil](/molmil-images/mine/5t0q) | Crystal structure of the Myc3 N-terminal domain [44-242] in complex with JAZ10 Jas domain [166-192] from arabidopsis | Descriptor: | Protein TIFY 9, Transcription factor MYC3 | Authors: | Ke, J, Zhang, F, Brunzelle, J.S, He, S.Y, Xu, H.E, Melcher, K. | Deposit date: | 2016-08-16 | Release date: | 2017-01-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural insights into alternative splicing-mediated desensitization of jasmonate signaling. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5T0F
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![BU of 5t0f by Molmil](/molmil-images/mine/5t0f) | Crystal structure of the Myc3 N-terminal domain [44-242] in complex with JAZ10 CMID domain [16-58] from arabidopsis | Descriptor: | Protein TIFY 9, Transcription factor MYC3 | Authors: | Ke, J, Zhang, F, Brunzelle, J.S, He, S.Y, Xu, H.E, Melcher, K. | Deposit date: | 2016-08-16 | Release date: | 2017-01-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into alternative splicing-mediated desensitization of jasmonate signaling. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5T5X
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6YGJ
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![BU of 6ygj by Molmil](/molmil-images/mine/6ygj) | |
8CK3
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![BU of 8ck3 by Molmil](/molmil-images/mine/8ck3) | STRUCTURE OF HIF2A-ARNT HETERODIMER IN COMPLEX WITH (S)-1-(3,5-Difluoro-phenyl)-5,5-difluoro-3-methanesulfonyl-5,6-dihydro-4H-cyclopenta[c]thiophen-4-ol | Descriptor: | (4~{S})-1-[3,5-bis(fluoranyl)phenyl]-5,5-bis(fluoranyl)-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol, Aryl hydrocarbon receptor nuclear translocator, DIMETHYL SULFOXIDE, ... | Authors: | Musil, D, Lehmannn, M, Diehl, L. | Deposit date: | 2023-02-14 | Release date: | 2023-07-19 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.707 Å) | Cite: | Discovery of Cycloalkyl[ c ]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2 alpha Inhibitors. J.Med.Chem., 66, 2023
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8CK8
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8CK4
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![BU of 8ck4 by Molmil](/molmil-images/mine/8ck4) | STRUCTURE OF HIF2A-ARNT HETERODIMER IN COMPLEX WITH (4S)-1-(3,5-difluorophenyl)-5,5-difluoro-3-methanesulfonyl-4,5,6,7-tetrahydro-2-benzothiophen-4-ol | Descriptor: | (4~{S})-1-[3,5-bis(fluoranyl)phenyl]-5,5-bis(fluoranyl)-3-methylsulfonyl-6,7-dihydro-4~{H}-2-benzothiophen-4-ol, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | Authors: | Musil, D. | Deposit date: | 2023-02-14 | Release date: | 2023-07-19 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Discovery of Cycloalkyl[ c ]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2 alpha Inhibitors. J.Med.Chem., 66, 2023
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8BTQ
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![BU of 8btq by Molmil](/molmil-images/mine/8btq) | |
3F1P
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![BU of 3f1p by Molmil](/molmil-images/mine/3f1p) | Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | Authors: | Scheuermann, T.H, Tomchick, D.R, Machius, M, Guo, Y, Bruick, R.K, Gardner, K.H. | Deposit date: | 2008-10-28 | Release date: | 2009-01-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.17 Å) | Cite: | Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc.Natl.Acad.Sci.USA, 106, 2009
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3F1O
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![BU of 3f1o by Molmil](/molmil-images/mine/3f1o) | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with an internally-bound artificial ligand | Descriptor: | 1,2-ETHANEDIOL, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, ... | Authors: | Scheuermann, T.H, Tomchick, D.R, Machius, M, Guo, Y, Bruick, R.K, Gardner, K.H. | Deposit date: | 2008-10-28 | Release date: | 2009-01-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.598 Å) | Cite: | Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc.Natl.Acad.Sci.USA, 106, 2009
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3F1N
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![BU of 3f1n by Molmil](/molmil-images/mine/3f1n) | Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with internally bound ethylene glycol. | Descriptor: | 1,2-ETHANEDIOL, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | Authors: | Scheuermann, T.H, Tomchick, D.R, Machius, M, Guo, Y, Bruick, R.K, Gardner, K.H. | Deposit date: | 2008-10-28 | Release date: | 2009-01-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.479 Å) | Cite: | Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc.Natl.Acad.Sci.USA, 106, 2009
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1U9A
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![BU of 1u9a by Molmil](/molmil-images/mine/1u9a) | HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9 | Descriptor: | UBIQUITIN-CONJUGATING ENZYME | Authors: | Tong, H, Hateboer, G, Perrakis, A, Bernards, R, Sixma, T.K. | Deposit date: | 1997-02-11 | Release date: | 1997-05-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system. J.Biol.Chem., 272, 1997
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1U9B
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![BU of 1u9b by Molmil](/molmil-images/mine/1u9b) | MURINE/HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9 | Descriptor: | UBIQUITIN-CONJUGATING ENZYME E9 | Authors: | Tong, H, Hateboer, G, Perrakis, A, Bernards, R, Sixma, T.K. | Deposit date: | 1997-05-20 | Release date: | 1997-07-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system. J.Biol.Chem., 272, 1997
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5F74
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![BU of 5f74 by Molmil](/molmil-images/mine/5f74) | Crystal structure of ChREBP:14-3-3 complex bound with AMP | Descriptor: | 14-3-3 protein beta/alpha, ADENOSINE MONOPHOSPHATE, Carbohydrate-responsive element-binding protein | Authors: | Jung, H, Uyeda, K. | Deposit date: | 2015-12-07 | Release date: | 2016-03-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR. J.Biol.Chem., 291, 2016
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6U2U
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![BU of 6u2u by Molmil](/molmil-images/mine/6u2u) | |
6A5S
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![BU of 6a5s by Molmil](/molmil-images/mine/6a5s) | Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif | Descriptor: | 14-3-3 protein gamma, MAGNESIUM ION, SODIUM ION, ... | Authors: | Xu, Y, Ren, J.Q, Feng, W. | Deposit date: | 2018-06-25 | Release date: | 2019-02-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 2019
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4ZQD
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![BU of 4zqd by Molmil](/molmil-images/mine/4zqd) | Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with the Benzoxadiazole Antagonist 0X3 | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine | Authors: | Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. | Deposit date: | 2015-05-09 | Release date: | 2015-08-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Structural integration in hypoxia-inducible factors. Nature, 524, 2015
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4ZPR
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![BU of 4zpr by Molmil](/molmil-images/mine/4zpr) | Crystal Structure of the Heterodimeric HIF-1a:ARNT Complex with HRE DNA | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ... | Authors: | Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. | Deposit date: | 2015-05-08 | Release date: | 2015-08-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.902 Å) | Cite: | Structural integration in hypoxia-inducible factors. Nature, 524, 2015
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