8CK3

STRUCTURE OF HIF2A-ARNT HETERODIMER IN COMPLEX WITH (S)-1-(3,5-Difluoro-phenyl)-5,5-difluoro-3-methanesulfonyl-5,6-dihydro-4H-cyclopenta[c]thiophen-4-ol

Summary for 8CK3

Entry DOI	10.2210/pdb8ck3/pdb
Descriptor	Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, (4~{S})-1-[3,5-bis(fluoranyl)phenyl]-5,5-bis(fluoranyl)-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol, ... (5 entities in total)
Functional Keywords	hypoxia-inducible factor, bhlh-pas, hif-2-alpha, arnt, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	28339.99
Authors	Musil, D.,Lehmannn, M.,Diehl, L. (deposition date: 2023-02-14, release date: 2023-07-19, Last modification date: 2023-07-26)
Primary citation	Buchstaller, H.P.,Sala-Hojman, A.,Leiendecker, M.,Albers, J.,Anlauf, U.,Berges, N.,Dong, L.,Fuchss, T.,Germann, M.,Knehans, T.,Krier, M.,Lecomte, M.,Muller, D.,Muller, S.R.,Leuthner, B.,Lindemann, R.,Musil, D.,Nowak, M.,Reither, V.,Rettig, C.,Schindler, C.E.M.,Pakulska, U.,Spuck, D.,Wegener, A.,Zarebski, A. Discovery of Cycloalkyl[ c ]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2 alpha Inhibitors. J.Med.Chem., 66:8666-8686, 2023 Cited by PubMed: 37403966 DOI: 10.1021/acs.jmedchem.3c00332 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.707 Å)

Structure validation