8CK8

STRUCTURE OF HIF2A-ARNT HETERODIMER IN COMPLEX WITH (S)-1-Cyclohexyloxy-5,5-difluoro-3-methanesulfonyl-5,6-dihydro-4H-cyclopenta[c]thiophen-4-ol

Summary for 8CK8

• Entry DOI: 10.2210/pdb8ck8/pdb
• Descriptor: Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, (4~{S})-1-cyclohexyloxy-5,5-bis(fluoranyl)-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol, ... (4 entities in total)
• Functional Keywords: hypoxia-inducible factor, bhlh-pas, hif-2-alpha, arnt, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 28247.92

Authors

Musil, D. (deposition date: 2023-02-14, release date: 2023-07-19, Last modification date: 2023-07-26)

• Primary citation: Buchstaller, H.P.,Sala-Hojman, A.,Leiendecker, M.,Albers, J.,Anlauf, U.,Berges, N.,Dong, L.,Fuchss, T.,Germann, M.,Knehans, T.,Krier, M.,Lecomte, M.,Muller, D.,Muller, S.R.,Leuthner, B.,Lindemann, R.,Musil, D.,Nowak, M.,Reither, V.,Rettig, C.,Schindler, C.E.M.,Pakulska, U.,Spuck, D.,Wegener, A.,Zarebski, A.; Discovery of Cycloalkyl[ c ]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2 alpha Inhibitors.; J.Med.Chem., 66:8666-8686, 2023; PubMed: 37403966; DOI: 10.1021/acs.jmedchem.3c00332

Experimental method

X-RAY DIFFRACTION (2.302 Å)