8CK8
STRUCTURE OF HIF2A-ARNT HETERODIMER IN COMPLEX WITH (S)-1-Cyclohexyloxy-5,5-difluoro-3-methanesulfonyl-5,6-dihydro-4H-cyclopenta[c]thiophen-4-ol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Endothelial PAS domain-containing protein 1 | polymer | 118 | 13595.4 | 1 | UniProt (Q99814) Pfam (PF14598) In PDB | Homo sapiens (human) | EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF-2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2 |
2 | B | Aryl hydrocarbon receptor nuclear translocator | polymer | 122 | 14300.1 | 1 | UniProt (P27540) Pfam (PF14598) In PDB | Homo sapiens (human) | ARNT protein,Class E basic helix-loop-helix protein 2,bHLHe2,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF-1-beta,HIF1-beta |
3 | A | (4~{S})-1-cyclohexyloxy-5,5-bis(fluoranyl)-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol | non-polymer | 352.4 | 1 | Chemie (UYF) | |||
4 | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A: 239 - 350 (UniProt: Q99814)
B: 356 - 470 (UniProt: P27540)
PDB | External Database | Details |
---|---|---|
Gly 234 | - | expression tag |
Glu 235 | - | expression tag |
Phe 236 | - | expression tag |
Lys 237 | - | expression tag |
Gly 238 | - | expression tag |
Glu 247 | Arg 247 | conflict |
Gly 351 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 350 | - | expression tag |
Glu 351 | - | expression tag |
Phe 352 | - | expression tag |
Lys 353 | - | expression tag |
Gly 354 | - | expression tag |
Leu 355 | - | expression tag |
Arg 362 | Glu 362 | conflict |
Gly 471 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 27895.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 352.4 | |
All* | Total formula weight | 28247.9 |