6YGJ

small-molecule stabilizer of 14-3-3 and the Carbohydrate Response Element Binding Protein (ChREBP) protein-protein interaction

Summary for 6YGJ

Entry DOI	10.2210/pdb6ygj/pdb
Descriptor	14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, [2-[2-oxidanylidene-2-(2-phenylethylamino)ethoxy]phenyl]phosphonic acid, ... (5 entities in total)
Functional Keywords	14-3-3, stabilizer, protein-protein interaction, chrebp, small molecule, structural protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	59136.56
Authors	Ottmann, C.,Visser, E.J. (deposition date: 2020-03-27, release date: 2020-09-16, Last modification date: 2024-01-24)
Primary citation	Sijbesma, E.,Visser, E.,Plitzko, K.,Thiel, P.,Milroy, L.G.,Kaiser, M.,Brunsveld, L.,Ottmann, C. Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions. Nat Commun, 11:3954-3954, 2020 Cited by PubMed: 32770072 DOI: 10.1038/s41467-020-17741-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.07 Å)

Structure validation