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6YGJ

small-molecule stabilizer of 14-3-3 and the Carbohydrate Response Element Binding Protein (ChREBP) protein-protein interaction

Functional Information from GO Data
ChainGOidnamespacecontents
A0004860molecular_functionprotein kinase inhibitor activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005773cellular_componentvacuole
A0005774cellular_componentvacuolar membrane
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0006605biological_processprotein targeting
A0007165biological_processsignal transduction
A0008104biological_processprotein localization
A0016020cellular_componentmembrane
A0019899molecular_functionenzyme binding
A0019904molecular_functionprotein domain specific binding
A0035308biological_processnegative regulation of protein dephosphorylation
A0042470cellular_componentmelanosome
A0042802molecular_functionidentical protein binding
A0042826molecular_functionhistone deacetylase binding
A0043085biological_processpositive regulation of catalytic activity
A0045296molecular_functioncadherin binding
A0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
A0048471cellular_componentperinuclear region of cytoplasm
A0050815molecular_functionphosphoserine residue binding
A0051219molecular_functionphosphoprotein binding
A0051220biological_processcytoplasmic sequestering of protein
A0070062cellular_componentextracellular exosome
F0004860molecular_functionprotein kinase inhibitor activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005773cellular_componentvacuole
F0005774cellular_componentvacuolar membrane
F0005829cellular_componentcytosol
F0005925cellular_componentfocal adhesion
F0006605biological_processprotein targeting
F0007165biological_processsignal transduction
F0008104biological_processprotein localization
F0016020cellular_componentmembrane
F0019899molecular_functionenzyme binding
F0019904molecular_functionprotein domain specific binding
F0035308biological_processnegative regulation of protein dephosphorylation
F0042470cellular_componentmelanosome
F0042802molecular_functionidentical protein binding
F0042826molecular_functionhistone deacetylase binding
F0043085biological_processpositive regulation of catalytic activity
F0045296molecular_functioncadherin binding
F0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
F0048471cellular_componentperinuclear region of cytoplasm
F0050815molecular_functionphosphoserine residue binding
F0051219molecular_functionphosphoprotein binding
F0051220biological_processcytoplasmic sequestering of protein
F0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue OQE A 301
ChainResidue
ALYS51
AARG58
AARG129
ATYR130
BILE120
BASN124
BTRP127
BARG128

site_idAC2
Number of Residues8
Detailsbinding site for residue OQE F 301
ChainResidue
FARG58
FARG129
FTYR130
FLEU174
IASN124
ITRP127
IARG128
FLYS51

Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG43-VAL53
FARG43-VAL53

site_idPS00797
Number of Residues20
Details1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
ChainResidueDetails
ATYR213-SER232
FTYR213-SER232

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Interaction with phosphoserine on interacting protein => ECO:0000250
ChainResidueDetails
FARG58
FARG129

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
FTHR2

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P27348
ChainResidueDetails
FLYS5

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P27348
ChainResidueDetails
FLYS51

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9CQV8
ChainResidueDetails
FSER60
ALYS117

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
FLYS70
FLYS117

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q9CQV8
ChainResidueDetails
FTYR84
FTYR106

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68251
ChainResidueDetails
FSER186

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
FSER232

site_idSWS_FT_FI10
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P27348
ChainResidueDetails
FLYS51

222926

PDB entries from 2024-07-24

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