6YGJ
small-molecule stabilizer of 14-3-3 and the Carbohydrate Response Element Binding Protein (ChREBP) protein-protein interaction
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 14-3-3 protein beta/alpha | polymer | 229 | 26348.6 | 1 | UniProt (P31946) Pfam (PF00244) In PDB | Homo sapiens (Human) | Protein 1054,Protein kinase C inhibitor protein 1,KCIP-1 |
| 2 | B, I | Carbohydrate-responsive element-binding protein | polymer | 21 | 2768.2 | 2 | UniProt (Q9NP71) In PDB | Homo sapiens | ChREBP,Class D basic helix-loop-helix protein 14,bHLHd14,MLX interactor,MLX-interacting protein-like,WS basic-helix-loop-helix leucine zipper protein,WS-bHLH,Williams-Beuren syndrome chromosomal region 14 protein |
| 3 | F | 14-3-3 protein beta/alpha | polymer | 231 | 26580.9 | 1 | UniProt (P31946) Pfam (PF00244) In PDB | Homo sapiens (Human) | Protein 1054,Protein kinase C inhibitor protein 1,KCIP-1 |
| 4 | A, F | [2-[2-oxidanylidene-2-(2-phenylethylamino)ethoxy]phenyl]phosphonic acid | non-polymer | 335.3 | 2 | Chemie (OQE) | |||
| 5 | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
B, I: 117 - 137 (UniProt: Q9NP71)
| PDB | External Database | Details |
|---|---|---|
| Gln 136 | Lys 136 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 58466.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 670.6 | |
| All* | Total formula weight | 59136.6 |
