3F1N
Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with internally bound ethylene glycol.
Summary for 3F1N
Entry DOI | 10.2210/pdb3f1n/pdb |
Related | 1P97 1X0O 2A24 2B02 3F1O 3F1P |
Descriptor | Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | pas domain, heterodimer, internal cavity, activator, angiogenesis, congenital erythrocytosis, developmental protein, differentiation, disease mutation, dna-binding, hydroxylation, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation, alternative splicing, polymorphism |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q99814 P27540 |
Total number of polymer chains | 2 |
Total formula weight | 27967.60 |
Authors | Scheuermann, T.H.,Tomchick, D.R.,Machius, M.,Guo, Y.,Bruick, R.K.,Gardner, K.H. (deposition date: 2008-10-28, release date: 2009-01-20, Last modification date: 2023-09-06) |
Primary citation | Scheuermann, T.H.,Tomchick, D.R.,Machius, M.,Guo, Y.,Bruick, R.K.,Gardner, K.H. Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc.Natl.Acad.Sci.USA, 106:450-455, 2009 Cited by PubMed: 19129502DOI: 10.1073/pnas.0808092106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.479 Å) |
Structure validation
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