3F1N
Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with internally bound ethylene glycol.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Endothelial PAS domain-containing protein 1 | polymer | 117 | 13538.3 | 1 | UniProt (Q99814) Pfam (PF14598) In PDB | Homo sapiens (Human) | EPAS-1, Member of PAS protein 2, Basic-helix-loop-helix-PAS protein MOP2, Hypoxia-inducible factor 2 alpha, HIF-2 alpha, HIF2 alpha, HIF-1 alpha-like factor, HLF |
2 | B | Aryl hydrocarbon receptor nuclear translocator | polymer | 121 | 14243.1 | 1 | UniProt (P27540) Pfam (PF14598) In PDB | Homo sapiens (Human) | ARNT protein, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1 beta, HIF-1 beta |
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
4 | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A: 239 - 350 (UniProt: Q99814)
B: 356 - 470 (UniProt: P27540)
PDB | External Database | Details |
---|---|---|
Gly 234 | - | expression tag |
Glu 235 | - | expression tag |
Phe 236 | - | expression tag |
Lys 237 | - | expression tag |
Gly 238 | - | expression tag |
Glu 247 | Arg 247 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 350 | - | expression tag |
Glu 351 | - | expression tag |
Phe 352 | - | expression tag |
Lys 353 | - | expression tag |
Gly 354 | - | expression tag |
Leu 355 | - | expression tag |
Arg 362 | Glu 362 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 27781.4 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 186.2 | |
All* | Total formula weight | 27967.6 |