3F1O

Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with an internally-bound artificial ligand

Summary for 3F1O

• Entry DOI: 10.2210/pdb3f1o/pdb
• Related: 1P97 1X0O 2A24 2B02 3F1N 3F1P
• Descriptor: Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, N-[2-nitro-4-(trifluoromethyl)phenyl]morpholin-4-amine, ... (5 entities in total)
• Functional Keywords: pas domain, heterodimer, internal cavity, activator, angiogenesis, congenital erythrocytosis, developmental protein, differentiation, disease mutation, dna-binding, hydroxylation, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation, alternative splicing, polymorphism
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q99814 P27540
• Total number of polymer chains: 2
• Total formula weight: 28134.69

Authors

Scheuermann, T.H.,Tomchick, D.R.,Machius, M.,Guo, Y.,Bruick, R.K.,Gardner, K.H. (deposition date: 2008-10-28, release date: 2009-01-20, Last modification date: 2023-09-06)

• Primary citation: Scheuermann, T.H.,Tomchick, D.R.,Machius, M.,Guo, Y.,Bruick, R.K.,Gardner, K.H.; Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.; Proc.Natl.Acad.Sci.USA, 106:450-455, 2009; PubMed: 19129502; DOI: 10.1073/pnas.0808092106

Experimental method

X-RAY DIFFRACTION (1.598 Å)