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6V9Y
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BU of 6v9y by Molmil
Structure of TRPA1 bound with A-967079, PMAL-C8
Descriptor: Transient receptor potential cation channel subfamily A member 1
Authors:Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D.
Deposit date:2019-12-16
Release date:2020-05-06
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Nature, 585, 2020
6V9X
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BU of 6v9x by Molmil
Structure of TRPA1 modified by iodoacetamide, PMAL-C8
Descriptor: Transient receptor potential cation channel subfamily A member 1
Authors:Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D.
Deposit date:2019-12-16
Release date:2020-05-06
Last modified:2020-09-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Nature, 585, 2020
6V9W
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BU of 6v9w by Molmil
Structure of TRPA1 (ligand-free) with bound calcium, LMNG
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily A member 1
Authors:Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D.
Deposit date:2019-12-16
Release date:2020-05-06
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Nature, 585, 2020
6V9V
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BU of 6v9v by Molmil
Structure of TRPA1 modified by Bodipy-iodoacetamide with bound calcium, LMNG
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily A member 1, ~{N}-[[2,2-bis(fluoranyl)-10,12-dimethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-4-yl]methyl]ethanamide
Authors:Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D.
Deposit date:2019-12-16
Release date:2020-05-06
Last modified:2020-09-16
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Nature, 585, 2020
6V3G
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BU of 6v3g by Molmil
Cryo-EM structure of Ca2+-free hsSlo1 channel
Descriptor: Calcium-activated potassium channel subunit alpha-1
Authors:Tao, X, MacKinnon, R.
Deposit date:2019-11-25
Release date:2019-12-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
6V38
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BU of 6v38 by Molmil
Cryo-EM structure of Ca2+-bound hsSlo1 channel
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL, ...
Authors:Tao, X, MacKinnon, R.
Deposit date:2019-11-25
Release date:2019-12-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
6V35
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BU of 6v35 by Molmil
Cryo-EM structure of Ca2+-free hsSlo1-beta4 channel complex
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
Authors:Tao, X, MacKinnon, R.
Deposit date:2019-11-25
Release date:2019-12-25
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
6V22
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BU of 6v22 by Molmil
Cryo-EM structure of Ca2+-bound hsSlo1-beta4 channel complex
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Tao, X, MacKinnon, R.
Deposit date:2019-11-22
Release date:2019-12-25
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
6V1Y
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BU of 6v1y by Molmil
Cryo-EM Structure of the Hyperpolarization-Activated Potassium Channel KAT1: Octamer
Descriptor: (2S)-1-(nonanoyloxy)-3-(phosphonooxy)propan-2-yl tetradecanoate, (3beta,5beta,14beta,17alpha)-cholestan-3-ol, Potassium channel KAT1
Authors:Clark, M.D, Contreras, G.F, Shen, R, Perozo, E.
Deposit date:2019-11-21
Release date:2020-06-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Electromechanical coupling in the hyperpolarization-activated K + channel KAT1.
Nature, 583, 2020
6V1X
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BU of 6v1x by Molmil
Cryo-EM Structure of the Hyperpolarization-Activated Potassium Channel KAT1: Tetramer
Descriptor: (2S)-1-(nonanoyloxy)-3-(phosphonooxy)propan-2-yl tetradecanoate, (3beta,5beta,14beta,17alpha)-cholestan-3-ol, Potassium channel KAT1
Authors:Clark, M.D, Contreras, G.F, Shen, R, Perozo, E.
Deposit date:2019-11-21
Release date:2020-06-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Electromechanical coupling in the hyperpolarization-activated K + channel KAT1.
Nature, 583, 2020
6V1Q
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BU of 6v1q by Molmil
Two-pore channel 3
Descriptor: SODIUM ION, Two pore channel 3
Authors:Dickinson, M.S, Stroud, R.M.
Deposit date:2019-11-20
Release date:2019-12-04
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Resting state structure of the hyperdepolarization activated two-pore channel 3.
Proc.Natl.Acad.Sci.USA, 117, 2020
6V01
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BU of 6v01 by Molmil
structure of human KCNQ1-KCNE3-CaM complex with PIP2
Descriptor: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily E member 3, ...
Authors:Mackinnon, R, Sun, J.
Deposit date:2019-11-18
Release date:2019-12-04
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural Basis of Human KCNQ1 Modulation and Gating.
Cell, 180, 2020
6V00
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BU of 6v00 by Molmil
structure of human KCNQ1-KCNE3-CaM complex
Descriptor: CALCIUM ION, Calmodulin-1, MCherry fluorescent protein,Potassium voltage-gated channel subfamily E member 3, ...
Authors:Mackinnon, R, Sun, J.
Deposit date:2019-11-16
Release date:2019-12-04
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural Basis of Human KCNQ1 Modulation and Gating.
Cell, 180, 2020
6UZZ
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BU of 6uzz by Molmil
structure of human KCNQ1-CaM complex
Descriptor: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1
Authors:Mackinnon, R, Sun, J.
Deposit date:2019-11-16
Release date:2019-12-04
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural Basis of Human KCNQ1 Modulation and Gating.
Cell, 180, 2020
6UZA
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BU of 6uza by Molmil
Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473
Descriptor: 2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, 4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile, CHOLESTEROL HEMISUCCINATE, ...
Authors:Bai, Y, Yu, X, Huang, X, Chen, H.
Deposit date:2019-11-14
Release date:2020-03-18
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structural basis for pharmacological modulation of the TRPC6 channel.
Elife, 9, 2020
6UZ8
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BU of 6uz8 by Molmil
Cryo-EM structure of human TRPC6 in complex with agonist AM-0883
Descriptor: (5-chloro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanone, 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, CHOLESTEROL HEMISUCCINATE, ...
Authors:Bai, Y, Yu, X, Huang, X, Chen, H.
Deposit date:2019-11-14
Release date:2020-03-18
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Structural basis for pharmacological modulation of the TRPC6 channel.
Elife, 9, 2020
6UZ3
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BU of 6uz3 by Molmil
Cardiac sodium channel
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jiang, D, Shi, H, Tonggu, L, Lenaeus, M.J, Zheng, N, Catterall, W.A.
Deposit date:2019-11-14
Release date:2020-01-01
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the Cardiac Sodium Channel.
Cell, 180, 2020
6UZ0
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BU of 6uz0 by Molmil
Cardiac sodium channel with flecainide
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jiang, D, Shi, H, Tonggu, L, Lenaeus, M.J, Zheng, N, Catterall, W.A.
Deposit date:2019-11-14
Release date:2020-01-01
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Structure of the Cardiac Sodium Channel.
Cell, 180, 2020
6UWM
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BU of 6uwm by Molmil
Single particle cryo-EM structure of KvAP
Descriptor: Voltage-gated potassium channel
Authors:Tao, X, MacKinnon, R.
Deposit date:2019-11-05
Release date:2019-12-04
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology.
Elife, 8, 2019
6UW9
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BU of 6uw9 by Molmil
Cryo-EM structure of the human TRPV3 K169A mutant in the presence of 2-APB, determined in lipid nanodisc
Descriptor: Transient receptor potential cation channel subfamily V member 3
Authors:Deng, Z, Yuan, P.
Deposit date:2019-11-04
Release date:2020-07-01
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.33 Å)
Cite:Gating of human TRPV3 in a lipid bilayer.
Nat.Struct.Mol.Biol., 27, 2020
6UW8
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BU of 6uw8 by Molmil
Cryo-EM structure of the human TRPV3 K169A mutant briefly exposed to 2-APB for 3 minutes, determined in lipid nanodisc
Descriptor: Transient receptor potential cation channel subfamily V member 3
Authors:Deng, Z, Yuan, P.
Deposit date:2019-11-04
Release date:2020-07-01
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.02 Å)
Cite:Gating of human TRPV3 in a lipid bilayer.
Nat.Struct.Mol.Biol., 27, 2020
6UW6
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BU of 6uw6 by Molmil
Cryo-EM structure of the human TRPV3 K169A mutant determined in lipid nanodisc
Descriptor: Transient receptor potential cation channel subfamily V member 3, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
Authors:Deng, Z, Yuan, P.
Deposit date:2019-11-04
Release date:2020-07-01
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Gating of human TRPV3 in a lipid bilayer.
Nat.Struct.Mol.Biol., 27, 2020
6UW4
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BU of 6uw4 by Molmil
Cryo-EM structure of human TRPV3 determined in lipid nanodisc
Descriptor: SODIUM ION, Transient receptor potential cation channel subfamily V member 3, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
Authors:Deng, Z, Yuan, P.
Deposit date:2019-11-04
Release date:2020-07-01
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Gating of human TRPV3 in a lipid bilayer.
Nat.Struct.Mol.Biol., 27, 2020
6UQK
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BU of 6uqk by Molmil
Cryo-EM structure of type 3 IP3 receptor revealing presence of a self-binding peptide
Descriptor: ZINC ION, inositol 1,4,5-triphosphate receptor, type 3
Authors:Azumaya, C.M, Linton, E.A, Risener, C.J, Nakagawa, T, Karakas, E.
Deposit date:2019-10-20
Release date:2020-01-15
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist.
J.Biol.Chem., 295, 2020
6UQG
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BU of 6uqg by Molmil
Human HCN1 channel Y289D mutant
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Authors:Lee, C.-H, MacKinnon, R.
Deposit date:2019-10-19
Release date:2019-12-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Voltage Sensor Movements during Hyperpolarization in the HCN Channel.
Cell, 179, 2019

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