7D2K

Crystal structure of rat TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a

Summary for 7D2K

Entry DOI	10.2210/pdb7d2k/pdb
Descriptor	Transient receptor potential cation channel subfamily V member 6, CALCIUM ION, 1-(5-bromanylpyridin-3-yl)-4-[4-(3-methylphenyl)cyclohexyl]piperazin-4-ium (3 entities in total)
Functional Keywords	ion channels, trp channels, membrane proteins, transport protein-inhibitor complex, transport protein/inhibitor
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	1
Total formula weight	78004.35
Authors	Singh, A.K.,Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2020-09-16, release date: 2021-10-06, Last modification date: 2023-11-29)
Primary citation	Bhardwaj, R.,Lindinger, S.,Neuberger, A.,Nadezhdin, K.D.,Singh, A.K.,Cunha, M.R.,Derler, I.,Gyimesi, G.,Reymond, J.L.,Hediger, M.A.,Romanin, C.,Sobolevsky, A.I. Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6:-, 2020 Cited by PubMed: 33246965 DOI: 10.1126/sciadv.abe1508 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.698 Å)

Structure validation