PDB: 2317 resultsInfo pagesStatus searchChemie searchBIRD

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7Z71	Crystal structure of p63 DBD in complex with darpin C14 Descriptor: Darpin C14, Isoform 4 of Tumor protein 63, ZINC ION Authors: Chaikuad, A, Strubel, A, Doetsch, V, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2022-03-14 Release date: 2022-07-06 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Designed Ankyrin Repeat Proteins as a tool box for analyzing p63. Cell Death Differ., 29, 2022
5FO7	Crystal Structure of Human Complement C3b at 2.8 Angstrom resolution Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN Authors: Forneris, F, Wu, J, Xue, X, Gros, P. Deposit date: 2015-11-18 Release date: 2016-04-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
8H34	Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 hexameric complex Descriptor: Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... Authors: Hu, Y, Mao, Q, Chen, Z, Sun, L. Deposit date: 2022-10-07 Release date: 2023-10-11 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (7.99 Å) Cite: Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
8H33	Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex Descriptor: Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... Authors: Hu, Y, Mao, Q, Chen, Z, Sun, L. Deposit date: 2022-10-07 Release date: 2023-10-11 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (7.86 Å) Cite: Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
8H3Q	Cryo-EM Structure of the CAND1-Cul3-Rbx1 complex Descriptor: Cullin-3, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... Authors: Hu, Y, Mao, Q, Chen, Z, Sun, L. Deposit date: 2022-10-09 Release date: 2023-10-11 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.76 Å) Cite: Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
7QWR	Structure of the ribosome-nascent chain containing an ER signal sequence in complex with NAC Descriptor: 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Jomaa, A, Gamerdinger, M, Hsieh, H, Wallisch, A, Chandrasekaran, V, Ulusoy, Z, Scaiola, A, Hegde, R, Shan, S, Ban, N, Deuerling, E. Deposit date: 2022-01-25 Release date: 2022-03-09 Last modified: 2022-03-23 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting. Science, 375, 2022
7QWQ	Ternary complex of ribosome nascent chain with SRP and NAC Descriptor: 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Jomaa, A, Gamerdinger, M, Hsieh, H, Wallisch, A, Chandrasekaran, V, Ulusoy, Z, Scaiola, A, Hegde, R, Shan, S, Ban, N, Deuerling, E. Deposit date: 2022-01-25 Release date: 2022-03-16 Last modified: 2022-03-30 Method: ELECTRON MICROSCOPY (2.83 Å) Cite: Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting. Science, 375, 2022
6COX	CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A SELECTIVE INHIBITOR, SC-558 IN I222 SPACE GROUP Descriptor: 1-PHENYLSULFONAMIDE-3-TRIFLUOROMETHYL-5-PARABROMOPHENYLPYRAZOLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOOXYGENASE-2, ... Authors: Kurumbail, R, Stallings, W. Deposit date: 1996-12-18 Release date: 1997-12-24 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature, 384, 1996
5XHZ	Crystal Structure Analysis of CIN85-SH3B in complex with ARAP1-P2 Descriptor: ACETATE ION, Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, ... Authors: Liu, W, Yang, W. Deposit date: 2017-04-25 Release date: 2018-04-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.319 Å) Cite: Biochemical and Structural Studies of the Interaction between ARAP1 and CIN85. Biochemistry, 57, 2018
2QZV	Draft Crystal Structure of the Vault Shell at 9 Angstroms Resolution Descriptor: Major vault protein Authors: Anderson, D.H, Kickhoefer, V.A, Sievers, S.A, Rome, L.H, Eisenberg, D. Deposit date: 2007-08-17 Release date: 2007-12-04 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (9 Å) Cite: Draft crystal structure of the vault shell at 9-A resolution. Plos Biol., 5, 2007
8AM0	Crystal structure of human T1061E PI3Kalpha in complex with its regulatory subunit and the inhibitor GDC-0077 (Inavolisib) Descriptor: (2R)-2-[[2-[(4S)-4-[bis(fluoranyl)methyl]-2-oxidanylidene-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Goncalves, M, Johnson, J.L, Roewer, K.M. Deposit date: 2022-08-02 Release date: 2023-12-13 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (2.818 Å) Cite: Epinephrine inhibits PI3K alpha via the Hippo kinases. Cell Rep, 42, 2023
3HR2	Low resolution, molecular envelope structure of type I collagen in situ determined by fiber diffraction. Single type I collagen molecule, post rigid body refinement, 'relaxed' Descriptor: Collagen alpha-1(I) chain, Collagen alpha-2(I) chain Authors: Orgel, J.P. Deposit date: 2009-06-08 Release date: 2009-07-14 Last modified: 2024-02-21 Method: FIBER DIFFRACTION (5.16 Å) Cite: Microfibrillar Structure of Type I Collagen in Situ. Proc.Natl.Acad.Sci.USA, 103, 2006
3HQV	Low resolution, molecular envelope structure of type I collagen in situ determined by fiber diffraction. Single type I collagen molecule, rigid body refinement Descriptor: Collagen alpha-1(I) chain, Collagen alpha-2(I) chain Authors: Orgel, J.P. Deposit date: 2009-06-08 Release date: 2009-07-14 Last modified: 2024-02-21 Method: FIBER DIFFRACTION (5.16 Å) Cite: Microfibrillar Structure of Type I Collagen in Situ Proc.Natl.Acad.Sci.USA, 103, 2006
5XAQ	Crystal structure of Animalia-specific tRNA deacylase from Mus musculus Descriptor: Probable D-tyrosyl-tRNA(Tyr) deacylase 2 Authors: Kuncha, K.S, Kattula, B, Sankarnarayanan, R. Deposit date: 2017-03-14 Release date: 2018-02-14 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.86 Å) Cite: A chiral selectivity relaxed paralog of DTD for proofreading tRNA mischarging in Animalia Nat Commun, 9, 2018
3PGH	CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A NON-SELECTIVE INHIBITOR, FLURBIPROFEN Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOOXYGENASE-2, FLURBIPROFEN, ... Authors: Kurumbail, R, Stallings, W. Deposit date: 1996-12-18 Release date: 1997-12-24 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature, 384, 1996
4COX	CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A NON-SELECTIVE INHIBITOR, INDOMETHACIN Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOOXYGENASE-2, INDOMETHACIN, ... Authors: Kurumbail, R, Stallings, W. Deposit date: 1996-12-18 Release date: 1997-12-24 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature, 384, 1996
5FO9	Crystal Structure of Human Complement C3b in Complex with CR1 (CCP15- 17) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, ... Authors: Forneris, F, Wu, J, Xue, X, Gros, P. Deposit date: 2015-11-18 Release date: 2016-04-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
5FR2	Farnesylated RhoA-GDP in complex with RhoGDI-alpha, lysine acetylated at K178 Descriptor: FARNESYL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Kuhlmann, N, Wroblowski, S, Knyphausen, P, de Boor, S, Brenig, J, Zienert, A.Y, Meyer-Teschendorf, K, Praefcke, G.J.K, Nolte, H, Krueger, M, Schacherl, M, Baumann, U, James, L.C, Chin, J.W, Lammers, M. Deposit date: 2015-12-15 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Structural and Mechanistic Insights Into the Regulation of the Fundamental Rho-Regulator Rhogdi Alpha by Lysine Acetylation. J.Biol.Chem., 291, 2016
5JHG	Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11 Descriptor: GLYCEROL, Rho guanine nucleotide exchange factor 11, Transforming protein RhoA Authors: Wang, R, Chen, Q, Zhang, H, Yan, Z, Li, J, Miao, L, Wang, F. Deposit date: 2016-04-21 Release date: 2017-04-26 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and ARHGEF11 To Be Published
2QJB	Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB Descriptor: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, CHLORIDE ION Authors: Kotzsch, A, Mueller, T.D. Deposit date: 2007-07-06 Release date: 2008-01-15 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283, 2008
2QJA	Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B12 Descriptor: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA Authors: Kotzsch, A, Mueller, T.D. Deposit date: 2007-07-06 Release date: 2008-01-15 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283, 2008
1LEW	CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A Descriptor: Mitogen-activated protein kinase 14, Myocyte-specific enhancer factor 2A Authors: Chang, C.-I, Xu, B.-E, Akella, R, Cobb, M.H, Goldsmith, E.J. Deposit date: 2002-04-10 Release date: 2002-07-10 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol.Cell, 9, 2002
4D0N	AKAP13 (AKAP-Lbc) RhoGEF domain in complex with RhoA Descriptor: 1,2-ETHANEDIOL, A-KINASE ANCHOR PROTEIN 13, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M. Deposit date: 2014-04-29 Release date: 2014-05-21 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex. Biochem.J., 464, 2014
5UOJ	THE STRUCTURE OF THE MAP KINASE P38 AT 2.1 ANGSTROMS RESOLUTION Descriptor: Mitogen-activated protein kinase 14 Authors: CHLEBOWICZ, J, WANG, Z, GOLDSMITH, E.J. Deposit date: 2017-01-31 Release date: 2017-02-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc. Natl. Acad. Sci. U.S.A., 94, 1997
5COX	UNINHIBITED MOUSE CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOOXYGENASE-2, PROTOPORPHYRIN IX CONTAINING FE Authors: Kurumbail, R, Stallings, W. Deposit date: 1996-12-18 Release date: 1997-12-24 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature, 384, 1996

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