7QWR

Structure of the ribosome-nascent chain containing an ER signal sequence in complex with NAC

This is a non-PDB format compatible entry.

Summary for 7QWR

• Entry DOI: 10.2210/pdb7qwr/pdb
• EMDB information: 14192
• Descriptor: nascent chain pre-prolactin, Ribosomal_L18_c domain-containing protein, Ribosomal protein L32, ... (50 entities in total)
• Functional Keywords: ribosome, srp, nac, nascent chain, co-translational, endoplasmic reticulum, co-translational protein targeting, co-translational folding
• Biological source: Homo sapiens; More
• Total number of polymer chains: 48
• Total formula weight: 2543549.63

Authors

Jomaa, A.,Gamerdinger, M.,Hsieh, H.,Wallisch, A.,Chandrasekaran, V.,Ulusoy, Z.,Scaiola, A.,Hegde, R.,Shan, S.,Ban, N.,Deuerling, E. (deposition date: 2022-01-25, release date: 2022-03-09, Last modification date: 2022-03-23)

• Primary citation: Jomaa, A.,Gamerdinger, M.,Hsieh, H.H.,Wallisch, A.,Chandrasekaran, V.,Ulusoy, Z.,Scaiola, A.,Hegde, R.S.,Shan, S.O.,Ban, N.,Deuerling, E.; Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting.; Science, 375:839-844, 2022; PubMed: 35201867; DOI: 10.1126/science.abl6459

Experimental method

ELECTRON MICROSCOPY (2.9 Å)