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3PGH

CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A NON-SELECTIVE INHIBITOR, FLURBIPROFEN

Summary for 3PGH
Entry DOI10.2210/pdb3pgh/pdb
DescriptorCYCLOOXYGENASE-2, 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
Functional Keywordsperoxidase, dioxygenase, cyclooxygenase, nonsteroidal antiinflammatory drugs, inflammation, arthritis, prostaglandin, prostaglandin synthase, oxidoreductase
Biological sourceMus musculus (house mouse)
Total number of polymer chains4
Total formula weight275372.36
Authors
Kurumbail, R.,Stallings, W. (deposition date: 1996-12-18, release date: 1997-12-24, Last modification date: 2023-08-09)
Primary citationKurumbail, R.G.,Stevens, A.M.,Gierse, J.K.,McDonald, J.J.,Stegeman, R.A.,Pak, J.Y.,Gildehaus, D.,Miyashiro, J.M.,Penning, T.D.,Seibert, K.,Isakson, P.C.,Stallings, W.C.
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.
Nature, 384:644-648, 1996
Cited by
PubMed: 8967954
DOI: 10.1038/384644a0
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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