3PGH

CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A NON-SELECTIVE INHIBITOR, FLURBIPROFEN

Summary for 3PGH

DescriptorCYCLOOXYGENASE-2, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
Functional Keywordsperoxidase, dioxygenase, cyclooxygenase, nonsteroidal antiinflammatory drugs, inflammation, arthritis, prostaglandin, prostaglandin synthase, oxidoreductase
Biological sourceMus musculus (house mouse)
Cellular locationMicrosome membrane; Peripheral membrane protein Q05769
Total number of polymer chains4
Total molecular weight275372.36
Authors
Kurumbail, R.,Stallings, W. (deposition date: 1996-12-18, release date: 1997-12-24, Last modification date: 2011-07-13)
Primary citation
Kurumbail, R.G.,Stevens, A.M.,Gierse, J.K.,McDonald, J.J.,Stegeman, R.A.,Pak, J.Y.,Gildehaus, D.,Miyashiro, J.M.,Penning, T.D.,Seibert, K.,Isakson, P.C.,Stallings, W.C.
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.
Nature, 384:644-648, 1996
PubMed: 8967954 (PDB entries with the same primary citation)
DOI: 10.1038/384644a0
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers233.0%11.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3pgh
no rotation
Molmil generated image of 3pgh
rotated about x axis by 90°
Molmil generated image of 3pgh
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 3pgh
no rotation
Molmil generated image of 3pgh
rotated about x axis by 90°
Molmil generated image of 3pgh
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3pgh.pdb1.gz [186.29 KB])
Coordinate files for Biological unit (3pgh.pdb2.gz [186.54 KB])